Table 2.
LANS features and likelihoods across pathological diagnoses for the Mayo and ADNI cohorts
| Standard and advanced LANS features (meets feature/total) | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Mayo cohort | Age ≥ 75 | Mild syndrome | Hippocampal atrophy | Limbic hypometabolism | Absence of neocortical hypometabolism | Low neocortical tau likelihood |
|
| ||||||
| ADNC | 36/75 | 58/75 | 25/63 | 9/53 | 5/53 | 7/60 |
| ADN C/LATE-N C | 53/81 | 66/81 | 38/54 | 15/33 | 7/33 | 1/49 |
| LATE-NC | 8/9 | 8/9 | 3/4 | 3/4 | 1/4 | 5/7 |
|
| ||||||
| LANS likelihoods (only including patients with all features available) | ||||||
|
| ||||||
| Mayo cohort | ||||||
|
| ||||||
| Diagnosis | Low | Moderate | High | Highest | ||
|
| ||||||
| ADNC | 31 | 17 | 1 | 0 | ||
| ADN C/LATE-N C | 12 | 8 | 13 | 0 | ||
| LATE-NC | 0 | 0 | 2 | 2 | ||
|
| ||||||
| Standard and advanced LANS features | ||||||
|
| ||||||
| ADNI Cohort | Age ≥75 | Mild syndrome | Hippocampal atrophy | Limbic hypometabolism | Absence of neocortical hypometabolism | Low neocortical tau likelihood |
|
| ||||||
| ADNC | 15/26 | 20/26 | 11/26 | 1/18 | 2/18 | 1/22 |
| ADNC/LATE-N C | 12/19 | 12/19 | 15/19 | 4/13 | 1/13 | 0/17 |
| LATE-NC | 4/8 | 8/8 | 5/8 | 5/6 | 1/6 | 8/8 |
|
| ||||||
| LANS likelihoods (only including patients with all features available) | ||||||
|
| ||||||
| Diagnosis | Low | Moderate | High | Highest | ||
|
| ||||||
| ADNC | 11 | 7 | 0 | 0 | ||
| ADN C/LATE-N C | 8 | 3 | 1 | 0 | ||
| LATE-NC | 2 | 0 | 1 | 3 | ||
LANS = Limbic-predominant amnestic neurodegenerative syndrome; ADNC = Alzheimer’s disease neuropathological changes; LATE-NC = Limbic-predominant age-related TDP-43 encephalopathy neuropathological changes.