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. 2023 Nov 16;14:1265230. doi: 10.3389/fphar.2023.1265230

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Copyright © 2023 Khamis, Abdelkhalek, Abdellatif, Dwidar, Said, Ahmed, Wagdy, Elgarhy, Eltahan, Mohamed, Said Amer, Hanna, Ragab, Kishk, Wael, Sarhan, Saweres, Reda, Elkomy, Mohamed, Samy, Khafaga, Shaker, Yehia, Alanazi, Alassiri, Tîrziu, Bucur and Arisha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of BM-MSC administration on renal histological characteristics (H&E-stained sections) and the immunohistochemical staining of PCNA and P53, as indicated by a +ve immune reaction (A–K). (A) Photomicrograph of a renal cross-section stained by H&E (×400) shows a normal pattern of renal tissue in the control group, (B) photomicrograph of a renal cross-section stained by H&E (×400) shows collapsed and necrotic glomeruli with a widening of ‘Bowman’s space in the diabetic group, (C) photomicrograph of a renal cross-section stained by H&E (×400) shows a structured renal architecture in the BM-MSC-treated group compared to the normal control group, (D) photomicrograph of a renal cross-section immunostained with PCNA in the control group, (E) photomicrograph of a renal cross-section immunostained with PCNA in the diabetic group, (F) photomicrograph of a renal cross-section immunostained with PCNA in the BM-MSC-treated group, (G) PCNA immunostaining intensity (percent area), (H) photomicrograph of a renal cross-section immunostained with P53 in the control group, (I) photomicrograph of a renal cross-section immunostained with P53 in the diabetic group, (J) photomicrograph of a renal cross-section immunostained with P53 in the BM-MSC-treated group, and (K) P53 immunostaining intensity (percent area). Values represent mean ± SEM of 10 rats per group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.