Table 4.

Summary of keloid combination therapy.

Treatment category	Compound mode	Effect efficacy
Two combination therapy	TAC+5-FU	Improves the height, texture, and congestion condition (123)
	TAC+verapamil	Reduces the occurrence of telangiectasiasis and skin atrophy (125)
	TAC+BTX-A	Improves thickness and surface area (127)
Triple therapy	TAC+5-FU+PDL	Improves pigment, flexibility, and relieve itching (133)
	TAC+CO2+PDL	Relieves itch and pain (134)
	TAC+5-FU+sodium hyaluronate	Reduces pigmentation (135)
	Sandwich therapy	All flaps survived well and without serious complications (136)