Table 2.
Estimated effect sizes from dose-response meta-analysis.
| Outcome | Zuranolone dose |
||||
|---|---|---|---|---|---|
| 10 mg | 20 mg | 30 mg | 40 mg | 50 mg | |
| Depressive symptoms, SMD | −0.19 (−0.35, −0.03)∗ | −0.33 (−0.58, −0.09)∗ | −0.38 (−0.58, −0.17)∗ | −0.37 (−0.53, −0.21)∗ | −0.35 (−0.58, −0.12)∗ |
| Response rate (depression), OR | 1.62 (1.06, 2.48)∗ | 2.25 (1.16, 4.36)∗ | 2.41 (1.33, 4.35)∗ | 2.15 (1.45, 3.20)∗ | 1.82 (1.13, 2.93)∗ |
| Remission rate (depression), OR | 1.77 (1.13, 2.79)∗ | 2.56 (1.28, 5.14)∗ | 2.61 (1.41, 4.82)∗ | 2.09 (1.32, 3.30)∗ | 1.55 (0.81, 2.98) |
| Anxiety symptoms, SMD | −0.15 (−0.29, −0.01)∗ | −0.26 (−0.48, −0.03)∗ | −0.29 (−0.49, −0.08)∗ | −0.26 (−0.40, −0.13)∗ | −0.23 (−0.37, −0.08)∗ |
| Dropout rate, OR | 1.08 (0.85, 1.36) | 1.13 (0.79, 1.60) | 1.13 (0.83, 1.54) | 1.10 (0.79, 1.52) | 1.07 (0.64, 1.77) |
| Side effect rate, OR | 1.03 (0.87, 1.23) | 1.11 (0.85, 1.44) | 1.26 (1.00, 1.59)∗ | 1.50 (1.23, 1.83)∗ | 1.79 (1.35, 2.39)∗ |
Abbreviations: OR: odds ratio; SMD: standardized mean difference.
An asterisks indicates statistical significance.