Table 2.
Laboratory parameters of the pediatric SCD cohort
| Laboratory parameters at study entry, median (IQR) | Normal pediatric reference range | Total cohort (N = 180) | HC (n = 96) | BT (n = 84) | P value |
|---|---|---|---|---|---|
| Hb (g/dL) | 115-155 | 94 (84-101) | 87 (80-95) | 98 (93-106) | <.0001 |
| MCV (fL) | 77-96 | 86 (82-94) | 94 (86-99) | 85 (83-86) | <.0001 |
| RCC (×109/L) | 4-5.2 | 3.1 (2.5-3.5) | 2.6 (2.3-3) | 3.4 (3.2-3.6) | <.0001 |
| HCT (%) | 35-45 | 27 (23-29) | 24 (22-260) | 28 (27-30) | <.0001 |
| MCH (pg) | 25-33 | 30 (29-34) | 33 (31-37) | 29 (28-30) | <.0001 |
| MCHC (g/L) | 315-370 | 352 (343-362) | 361 (352-368) | 346 (340-350) | <.0001 |
| Platelets (×109/L) | 150-450 | 291 (204-389) | 313 (213-405) | 243 (184-365) | .007 |
| Leucocytes (×109/L) | 4.5-13.5 | 8.2 (6.3-9.7) | 7.6 (6-9.1) | 8.7 (6.7-11.1) | .0015 |
| Neutrophils (×109/L) | 1.5-8.0 | 3.7 (2.9-5.4) | 3.1 (2.2-4.1) | 5.1 (3.5-6.7) | <.0001 |
| HbS, % | NA | 58 (21-77) | 76 (72-90) | 20 (14-27) | <.0001 |
| HbF, % | 0-2 | 10 (3-16) | 16 (12-21) | 2.4 (1.4-4) | <.0001 |
| Reticulocyte (×109/L) | 14-99 | 184 (141-256) | 171 (141-228) | 200 (138-285) | .09 |
| Reticulocyte (%) | 0.4-1.9 | 6 (5-9) | 6 (5-9) | 6 (4-8) | .13 |
| Bilirubin (μmol/L) | 0-21 | 36 (25-55) | 33 (21-51) | 40 (27-57) | .02 |
| LDH (U/L) | 230-600 | 807 (290-1051) | 898 (689-1052) | 678 (515-968) | .0007 |
| Urea (mmol/L) | 4 (2.9-4.7) | 3 (2.4-3.6) | 5 (3.8-6) | <.0001 | |
| Creatinine (μmol/L) | 40 (31-50) | 38 (29-47) | 44 (35-51) | .01 | |
| AST (U/L) | <40 | 41 (33-54) | 43 (34-54) | 38 (32-53) | .22 |
| ALT (U/L) | <30 | 19 (14-26) | 20 (14-26) | 18 (13-24.3) | .46 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; HCT, hematocrit; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscle value; RCC, red cell count.