. 2023 Nov 7;55:101193. doi: 10.1016/j.nmni.2023.101193

Table 2.

Screening of 601 compounds of MMV Pathogen Box and Pandemic Response Box against PDR K. pneumoniae.

Compounds	Triplicates			Avg OD	% IG	Pf(CFU/ml)	MIC (μM)
Compounds	OD1	OD2	OD3	Avg OD	% IG	Pf(CFU/ml)	MIC (μM)
MMV1580854	0.082	0.081	0.067	0.076	94.60	1.3 × 10⁶	≥2
MMV1579788	0.073	0.063	0.093	0.076	94.65	9.4 × 10⁶	≥5
Eravacycline	0.095	0.081	0.084	0.086	93.13	2.8 × 10⁷	≥2
Epetraborole	0.078	0.091	0.047	0.072	95.29	8.2 × 10⁴	≥2
MMV1578564	0.09	0.057	0.048	0.065	96.32	9.0 × 10⁵	≥2

Inhibition of the compounds is represented as %IG (Percentage of growth inhibition) based on the optical density (OD) at 600 nm. The persister subpopulation is denoted as PF(Persister frequency)in the table as CFU/ml units. Minimum Inhibitory Concentration (MIC) at which the compounds completely inhibit growth at a given concentration (μM) is represented.MMV ID for drugs: Eravacycline-MMV1578574, Epetraborole - MMV1578566.