Table 2.
Differences in T cell subsets in subgroups of PAI patients compared to healthy controls.
| T cells | CAH (1) | BADx (2) | AD (3) | Controls (4) | p-value |
|---|---|---|---|---|---|
| CD3+ T cells | 61.5 (58.0 – 69.1) | 53.7 (47.5 – 61.0) | 57.3 (51.8 – 62.3) | 57.4 (52.5 -63.4) | 0.0063(1vs.2) |
| CD4+ T cells | 68.2 (60.7 – 75.9) | 63.9 (49.0 – 82.7) | 79.4 (73.5 – 84.5) | 77.1 (71.2 – 83.7) | 0.0003(1/2vs.3/4) |
| IFN-γ+ TH-cells (Th1) | 12.9 (7.7 – 19.0) | 17.4 (8.9 – 25.9) | 8.1 (4.8 – 16.4) | 18.0 (10.4 – 28.0) | 0.0026(3vs.2/4) |
| IL-4+ TH-cells (Th2) | 3.4 (2.4 – 5.3) | 5.8 (3.7 – 10.1) | 2.4 (1.6 – 3.9) | 4.4 (3.0 – 6.2) | 0.0011(3vs.2/4) |
| IL-17+ TH-cells (Th17) | 9.6 (5.1 – 15.6) | 11.4 (6.1 – 13.7) | 1.7 (1.2 – 2.4) | 8.7 (11.1 – 13.6) | <0.0001(3vs.1/2/4) |
| IL-9+ TH-cells (Th9) | 2.1 (0.9 – 3.8) | 3.3 (1.2 – 6.5) | 0.5 (0.2 – 0.7) | 0.2 (0.2 – 0.6) | <0.0001(1/2vs.3/4) |
| IL-22+ TH-cells (Th22) | 0.6 (0.4 – 1.1) | 2.9 (0.9 – 5.4) | 0.4 (0.2 – 1.0) | 0.8 (0.5 – 1.2) | <0.0001(1vs.2/4,2vs.4) |
| CD8+ T cells | 17.6 (12.4 – 23.4) | 22.5 (13.2 – 41.7) | 14.7 (9.7 – 19.0) | 7.8 (13.1 – 16.5) | 0.0009(2vs.4) |
| IFN-γ+ TC-cells (Tc1) | 39.2 (25.7 – 49.9) | 58.8 (30.2 – 66.1) | 39.0 (26.3 – 46.5) | 36.7 (56.2 – 69.2) | 0.0004(4vs.1/3) |
| IL-4+ TC-cells (Tc2) | 4.2 (3.0 – 7.0) | 14.5 (5.4 – 23.5) | 2.5 (1.2 – 5.9) | 6.8 (3.9 – 10.8) | <0.0001(2vs.1/3,3vs.4) |
| IL-17+ TC-cells (Tc17) | 12.6 (6.1 – 16.3) | 12.9 (8.4 – 18.2) | 1.9 (1.1 – 3.6) | 16.6 (13.5 – 18.9) | <0.0001(1vs.3/4,2vs.3,3vs.4) |
| IL-9+ TC-cells (Tc9) | 7.3 (4.1 – 15.6) | 13.2 (6.4 – 18.6) | 3.4 (2.4 – 7.9) | 4.2 (2.2 -8.9) | <0.0001(2vs.3/4) |
| IL-22+ TC-cells (Tc22) | 0.3 (0.1 – 0.9) | 1.4 (0.6 – 5.3) | 0.2 (0.04 – 1.0) | 0.5 (0.3 – 0.8) | <0.0001(2vs.1/3/4) |
P-value refers to group differences of Kruskal-Wallis test. Significant results of Dunn’s multiple comparisons are depicted as superscript numbers where CAH (1), BADx (2), AD (3) and Controls (4). Eg.: 1vs.2/3/4 depicts statistically significant differences in the following pairwise comparisons: “CAH and BADx”, “CAH and. AD” and “CAH and controls”.