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. 2023 Nov 16;14:1237016. doi: 10.3389/fimmu.2023.1237016

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Copyright © 2023 Krishnan, Sendra, Patel, Lad, Greene, Smyth, Gallaher, Herron, Scott, Genead and Tolentino

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Laser-induced choroidal neovascularization (CNV) model in humanized Siglec-11 transgenic mice. The mice’s eyes received a single IVT dose of either PolySia-NPs at low and high dose/eye or a 10% sucrose vehicle. After the treatment, CNV was induced by creating four single laser spots OU surrounding the optic nerve using a 532 nm diode laser. The representative micrographs show the lesion size from fundus imaging and fluorescein angiography (A) and retinal flat mount immunohistochemistry staining for Isolectin-B4 (B) on Day 8. The lesion size was evaluated and quantified at Day 8 for fluorescein angiography (C) and by Immunohistochemistry Staining with Isolectin-B4 (D).