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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Mol Neurobiol. 2023 Feb 18;60(6):3113–3129. doi: 10.1007/s12035-023-03263-5

Fig. 7.

Fig. 7

Role of α6*-nAChRs in EtOH inhibition of evoked dopamine release in the NAc. A Illustration showing the experimental framework wherein CIN-mediated DA release was recorded following blue light stimulation in ChAT-ChR2-eYFP mice. B, C Current vs time plots show representative DA release evoked by light stimulation before and after superfusion of 60 mM EtOH under control (B) vs MII (C) conditions. Insets show superimposed cyclic voltammograms at the peak of DA release and color plots show cyclic voltammograms over time before and after Con + EtOH vs MII + EtOH. Ethanol inhibits CIN-mediated DA release with block by MII. D Concentration response for EtOH (1–80 mM) effects on CIN-mediated DA release. D Ethanol significantly inhibited DA release at 60–80 mM. E Summary of EtOH effects on CIN-mediated DA release. MII significantly reduces EtOH inhibition of CIN-mediated DA release. Asterisks * and *** indicate significance levels p < 0.05, and p < 0.001, respectively