Table 1.
Results of two-sample bidirectional MR analysis of the causal effects between Constipation and CRC (include CC and RC).
| Exposures | Outcomes | Methods | Number of SNPs | Beta | SE | P-vale | OR | 95%CI |
|---|---|---|---|---|---|---|---|---|
| Constipation | CRC | MR Egger | 26 | 0.002 | 0.002 | 0.371 | 1.002 | 0.998, 1.005 |
| Weighted median | 26 | 0.002 | 0.001 | 0.213 | 1.002 | 0.999, 1.004 | ||
| Inverse variance weighted | 26 | 0.002 | 0.001 | 0.023 | 1.002 | 1.000, 1.004 | ||
| Simple mode | 26 | 0.000 | 0.002 | 0.913 | 1.000 | 0.996, 1.004 | ||
| Weighted mode | 26 | 0.000 | 0.002 | 0.915 | 1.000 | 0.997, 1.004 | ||
| CC | MR Egger | 4 | 0.024 | 0.022 | 0.392 | 1.024 | 0.981, 1.069 | |
| Weighted median | 4 | 0.002 | 0.001 | 0.155 | 1.002 | 0.999, 1.004 | ||
| Inverse variance weighted | 4 | 0.002 | 0.001 | 0.086 | 1.002 | 1.000, 1.004 | ||
| Simple mode | 4 | 0.002 | 0.002 | 0.380 | 1.002 | 0.998, 1.006 | ||
| Weighted mode | 4 | 0.002 | 0.002 | 0.370 | 1.002 | 0.998, 1.005 | ||
| RC | MR Egger | 3 | 3.574 | 1.626 | 0.272 | 35.649 | 1.472, 863.106 | |
| Weighted median | 3 | -0.157 | 0.448 | 0.726 | 0.855 | 0.355, 2.057 | ||
| Inverse variance weighted | 3 | -0.194 | 0.616 | 0.753 | 0.824 | 0.246, 2.756 | ||
| Simple mode | 3 | 1.420 | 1.272 | 0.380 | 4.137 | 0.342, 50.041 | ||
| Weighted mode | 3 | -0.657 | 0.407 | 0.248 | 0.518 | 0.233, 1.151 | ||
| CRC | Constipation | MR Egger | 28 | -1.271 | 4.987 | 0.801 | 0.281 | 0.000, 4932.099 |
| Weighted median | 28 | -0.564 | 2.087 | 0.787 | 0.569 | 0.010, 34.019 | ||
| Inverse variance weighted | 28 | -1.990 | 1.545 | 0.198 | 0.137 | 0.007, 2.824 | ||
| Simple mode | 28 | 1.403 | 4.192 | 0.740 | 4.067 | 0.001, 15052.811 | ||
| Weighted mode | 28 | 0.401 | 3.32 | 0.905 | 1.493 | 0.002, 1000.545 | ||
| CC | MR Egger | 7 | -1.719 | 180.121 | 0.993 | 0.179 | 8.540E-155, 3.770E+152 | |
| Weighted median | 7 | 16.285 | 11.736 | 0.165 | 1.181E07 | 0.001, 1.153E+17 | ||
| Inverse variance weighted | 7 | 13.553 | 9.902 | 0.171 | 7.693E05 | 0.003, 2.063E+14 | ||
| Simple mode | 7 | 22.757 | 20.004 | 0.299 | 7.643E09 | 7.160E-08, 8.160E+26 | ||
| Weighted mode | 7 | 21.071 | 18.778 | 0.305 | 1.416E09 | 1.470E-07, 1.370E+25 | ||
| RC | MR Egger | 46 | 0.08 | 3.892 | 0.984 | 1.083 | 0.001, 2227.158 | |
| Weighted median | 46 | -0.266 | 0.14 | 0.057 | 0.766 | 0.583, 1.008 | ||
| Inverse variance weighted | 46 | -0.235 | 0.121 | 0.053 | 0.791 | 0.623, 1.003 | ||
| Simple mode | 46 | -0.279 | 0.322 | 0.391 | 0.757 | 0.403, 1.422 | ||
| Weighted mode | 46 | -0.275 | 0.316 | 0.387 | 0.759 | 0.409, 1.109 |
MR, Mendelian Randomization; CRC, Colorectal Cancer; CC, Colon Cancer; RC, Rectal Cancer; SNP, Single Nucleotide Polymorphism.