Table 2.

the results of heterogeneity and sensitivity test.

MR analysis	Methods	Heterogeneity test				Sensitivity test
-	-	Q	df	Q-val	I2	Egger regression intercept	Standard error	Directionality P-value
Constipation on CRC	MR Egger	29.223	24	0.212	0.150	7.680E-05	2.000E-4	0.707
	Inverse variance weighted	29.399	25	0.248	0.179
Constipation on CC	MR Egger	0.607	2	0.738	2.294	-0.001	0.001	0.423
	Inverse variance weighted	1.606	3	0.658	0.868
Constipation on RC	MR Egger	0.034	1	0.854	28.439	-2.197	0.924	0.253
	Inverse variance weighted	5.688	2	0.058	0.648
CRC on Constipation	MR Egger	3.443	7	0.841	0.012	-0.002	0.010	0.880
	Inverse variance weighted	8.097	8	0.424	1.033
CC on Constipation	MR Egger	8.773	5	0.118	0.430	0.009	0.105	0.936
	Inverse variance weighted	8.785	6	0.186	0.317
RC on Constipation	MR Egger	4.112	44	1	9.700	-0.048	0.590	0.936
	Inverse variance weighted	4.119	45	1	9.926

MR, Mendelian Randomization; CRC, Colorectal Cancer; CC, Colon Cancer; RC, Rectal Cancer.