TABLE 1.
A brief description of each GWAS summary statistics.
| Combination | Ancestry | Sample size of exposure | PMID | Group | NSNP | R2 (%) | F |
|---|---|---|---|---|---|---|---|
| GERD-COPD | European | 129,080 cases, 473,524 controls | 34,187,846 | Discovery | 40 | 1.66 | 253.66 |
| Validation | 39 | 1.61 | 252.49 | ||||
| PUD-COPD | European | 16,666 cases, 439,661 controls | 33,608,531 | Discovery | 36 | 5.72 | 768.69 |
| Validation | 34 | 5.46 | 774.85 | ||||
| IBS-COPD | European | 53,400 cases, 433,201 controls | 34,741,163 | Discovery | 63 | 3.66 | 293.80 |
| CD-COPD | Mixed | 12,194 cases, 28,072 controls | 28,067,908 | Discovery | 50 | 55.40 | 999.21 |
| UC-COPD | Mixed | 12,366 cases, 33,609 controls | 28,067,908 | Discovery | 42 | 39.55 | 715.50 |
| FD-COPD | European | 8,875 cases, 320,387 controls | — | Discovery | 14 | 3.62 | 884.56 |
| NGE-COPD | European | 11,373 cases, 444,975 controls | 34,737,426 | Discovery | 19 | 3.78 | 944.44 |
| CP-COPD | Mixed | 15,902 European ancestry cases, 395,721 European ancestry controls, 397 East Asian ancestry cases, 176,232 East Asian ancestry controls | 34,594,039 | Discovery | 21 | 4.04 | 1180.00 |
| COPD-GERD | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 31 | 4.59 | 986.16 |
| European | 18,266 European cases, 311,286 European controls | — | Validation | 31 | 4.50 | 501.09 | |
| COPD-PUD | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 53 | 8.44 | 1104.63 |
| European | 18,266 European cases, 311,286 European controls | — | Validation | 70 | 10.42 | 547.53 | |
| COPD-IBS | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 60 | 12.37 | 1494.22 |
| COPD-IBS | European | 18,266 European cases, 311,286 European controls | — | Validation | 75 | 11.18 | 552.91 |
| COPD-CD | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 55 | 11.25 | 1464.44 |
| COPD-UC | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 55 | 11.25 | 1464.44 |
| COPD-FD | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 58 | 11.80 | 1464.72 |
| COPD-NGE | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 57 | 9.34 | 1148.39 |
| COPD-CP | Mixed | 13,530 European cases, 454,945 European controls, 4,017 East Asian cases, 162,653 East Asian controls | 34,594,039 | Discovery | 61 | 12.74 | 1520.40 |
| European | 18,266 European cases, 311,286 European controls | — | Validation | 76 | 10.99 | 535.02 |
NSNP, Number of SNPs; R2, exposure variance explained by all IVs; F, F-statistic; GERD, gastroesophageal reflux disease; PUD, peptic ulcer disease; IBS, irritable bowel syndrome; CD, Crohn’s disease; UC, ulcerative colitis; FD, functional dyspepsia; NGE, noninfectious gastroenteritis; CP, constipation; COPD, chronic obstructive pulmonary disease.