TABLE 1.

Genotype and allele frequencies.

Gene	Variant	Genotype	N	Frequency	Allele	Frequency	HWE p-value*	FIS
ABCB1	rs2032582	CC	56	0.354	C	0.611	0.684	−0.070
	(N = 158)	CA	77	0.487	A	0.370
		CT	4	0.025	T	0.019
		AA	19	0.120
		AT	2	0.013
		TT	0	0.000
	rs9282564	TT	155	0.886	T	0.943	1.000	−0.058
	(N = 175)	TC	20	0.114	C	0.057
		CC	0	0.000
CYP3A5	rs776746 (*3)	*1/*1	3	0.019	*1	0.108	0.521	0.069
	rs10264272 (*6)	*1/*3	28	0.177	*3	0.886
	rs41303343 (*7)	*3/*3	125	0.791	*6	0.003
	(N = 158)	*3/*6	1	0.006	*7	0.003
		*3/*7	1	0.006
CEP72	rs924607	CC	61	0.377	C	0.593	0.192	0.108
	(N = 162)	CT	70	0.432	T	0.407
		TT	31	0.191
ASNS	rs3832526	2R2R	101	0.605	2R	0.766	0.200	0.099
	(N = 167)	2R3R	54	0.323	3R	0.234
		3R3R	12	0.072
	rs1049674	TT	99	0.623	T	0.811	0.001	−0.229
	(N = 159)	TA	60	0.377	A	0.189
		AA	0	0.000
GRIA1	rs4958351	GG	80	0.516	G	0.710	0.440	0.064
	(N = 155)	GA	60	0.387	A	0.290
		AA	15	0.097
	rs11951398	CC	142	0.899	C	0.949	1.000	−0.050
	(N = 158)	CT	16	0.101	T	0.051
		TT	0	0.000

N, number of patients; HWE, Hardy–Weinberg equilibrium; *, Fisher’s exact test; FIS, inbreeding coefficient; CYP3A5*1, reference or native allele.

Bold-italic values represents the significative p- values