Table 2.
Comparative minimal inhibitory concentrations (µg/ml) for M. avium and M. paratuberculosis by the agar proportionality and BACTEC broth methods.
| Antibiotic/Inhibitor | ||||||||||||||
| AMI | CIP | GAT | RIF | STR | CLR | DSA | ||||||||
| Mycobacterial species/strain | Agar Broth | Agar Broth | Agar Broth | Agar Broth | Agar Broth | Agar Broth | Agar Broth | |||||||
| M. avium 25291 | 8.0 | 2.0 | ≤1.0 | 1.0 | ≤1.0 | 1.0 | ≤0.5 | 0.5 | ≤2.0 | 2.0 | 1.0 | ≤0.5 | 6.25 | 25.0 |
| MAP 43544 (Ben-A) | 8.0 | 4.0 | >4.0 | >4.0 | 2.0 | 4.0 | 8.0 | 8.0 | ≤2.0 | 2.0 | 2.0 | ≤0.5 | 12.5 | 12.5 |
| MAP Ben-B | 8.0 | >8.0 | >4.0 | >4.0 | 2.0 | >4.0 | 8.0 | >8.0 | ≤2.0 | 8.0 | 4.0 | ≤0.5 | 12.5 | 25.0 |
| MAP Kay | 8.0 | 8.0 | >4.0 | >4.0 | >4.0 | >4.0 | >8.0 | 8.0 | 4.0 | 8.0 | 4.0 | ≤0.5 | ≤25.0 | 25.0 |
| MAP Linda | 8.0 | 4.0 | >4.0 | >4.0 | 2.0 | 4.0 | >8.0 | 8.0 | 2.0 | 2.0 | 4.0 | ≤0.5 | 12.5 | 25.0 |
| MAP 47 ileum | 8.0 | ND | 4.0 | ND | 2.0 | ND | >8.0 | ND | ≤2.0 | ND | 4.0 | ND | ≤25.0 | 25.0 |
| MAP fecal | 8.0 | ND | >4.0 | ND | 2.0 | ND | >8.0 | ND | ≤2.0 | ND | 2.0 | ND | 17.0 | ND |
MAP, M. paratuberculosis; ND, not done due to erratic growth; AMI, amikacin; CIP, ciprofloxacin; GAT, gatifloxacin; RIF, rifampin; STR, streptomycin; CLR, clarithromycin; DSA, n-decanesulfonylacetamide.