Figure 3.

Distribution of monocyte subsets in histiocytoses according to vascular injury and disease activity. Comparison of the distribution of monocyte subsets according to (A) the presence of vascular injury (N=7) or not (N=10), and (B) to the achievement of a metabolic response (N=10) or not (N=7). Disease activity was established using the last metabolic evaluation with ¹⁸fluorodeoxyglucose positron emission tomography-computed tomography according to PERCIST criteria. Complete metabolic response was defined by normalization of all lesions to at or below standardized uptake value (SUV) of liver background. Partial metabolic response was defined by a ≥50% decrease in the sum of all target lesion baseline SUV. Progressive metabolic disease was defined by a ≥50% increase in the nadir sum of all target or new evaluable lesion SUV. Stable metabolic disease was defined as condition that did not meet previous criteria. Patients with "complete metabolic response" and "partial metabolic response" were considered as responders and patients with "stable metabolic disease" and "progressive metabolic disease" considered as non-responders.