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. 2023 Dec 1;108(12):3227–3243. doi: 10.3324/haematol.2023.282716

Figure 5.

Figure 5.

Heterogeneity of peripheral T-cell lymphoma, not otherwise specified. (A-G) Cytotoxic peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) with large cell morphology and TBX21 (Th1) phenotype. This PTCL, NOS is composed of large pleomorphic cells, with numerous apoptotic bodies (A, hematoxylin & eosin), expresses pan-T-cell markers (B, CD3 and C, CD5), CD4 (D) and cytotoxic markers (E, perforin). Although TBX21 (F) is negative, diffuse expression of CXCR3 (G) subclassifies this lymphoma as PTCL-TBX21. CD30, EBV, GATA3 and CCR4 are also negative (not shown). (H-N) PTCL, NOS with small to medium-sized cells and a GATA3 (Th2) phenotype. This PTCL, NOS comprises diffuse sheets of small to medium-sized cells, with irregular nuclei and occasionally an abundant clear cytoplasm (H, hematoxylin & eosin), is positive for pan-T-cell markers including CD2 (I), and CD4+ (J), and is negative for cytotoxic markers (K, TIA-1). In the absence of TBX21 and CXCR3 expression (not shown), diffuse positivity for GATA3 (L) and CCR4 (M) subclassifies this lymphoma as PTCL-GATA3. P53 protein is diffusely overexpressed (N), reflecting a mutated TP53 gene status (confirmed by sequencing).