Table 3.
Subgroup analyses of NLR and mortality risk in RA.
| Variable | All-cause mortality | Cardiovascular mortality | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | P value | P for inter- action |
HR (95% CI) | P value | P for inter- action |
|
| Overall | 2.44 (1.97, 3.01) | <0.001 | 2.52 (1.56, 4.07) | <0.001 | ||
| Sex | 0.659 | 0.684 | ||||
| Female | 2.53 (1.87, 3.44) | <0.001 | 2.08 (0.94, 4.58) | 0.07 | ||
| Male | 2.29 (1.7, 3.09) | <0.001 | 2.62 (1.42, 4.85) | 0.002 | ||
| Age group | 0.536 | 0.927 | ||||
| <60 years | 1.71 (0.83, 3.53) | 0.144 | 1.85 (0.21, 16.55) | 0.582 | ||
| ≥60 years | 2.15 (1.72, 2.69) | <0.001 | 2.13 (1.3, 3.49) | 0.003 | ||
| Race/ethnicity | 0.863 | 0.014 | ||||
| White | 2.33 (1.8, 3.02) | <0.001 | 3.73 (2.14, 6.51) | <0.001 | ||
| Other | 2.24 (1.53, 3.28) | <0.001 | 0.29 (0.04, 2.16) | 0.229 | ||
| Educational attainment | 0.735 | 0.683 | ||||
| Less than 9th grade | 2.00 (1.24, 3.22) | 0.004 | 1.63 (0.55, 4.86) | 0.378 | ||
| 9-11th grade | 2.99 (1.86, 4.8) | <0.001 | 2.46 (0.8, 7.55) | 0.116 | ||
| High school graduate | 2.46 (1.67, 3.61) | <0.001 | 3.22 (1.44, 7.17) | 0.004 | ||
| Some college | 2.69 (1.63, 4.46) | <0.001 | 2.25 (0.58, 8.72) | 0.239 | ||
| College graduate or above | 2.58 (1.3, 5.12) | 0.007 | 6.33 (1.05, 38.02) | 0.044 | ||
| BMI group | 0.873 | 0.753 | ||||
| Underweight | 5.32 (0.74, 38.12) | 0.096 | 4.87 (0.3, 77.93) | 0.263 | ||
| Normal | 2.29 (1.54, 3.39) | <0.001 | 3.21 (1.43, 7.25) | 0.005 | ||
| Overweight | 2.54 (1.77, 3.65) | <0.001 | 2.00 (0.65, 6.15) | 0.226 | ||
| Obese | 2.36 (1.64, 3.4) | <0.001 | 2.13 (1, 4.54) | 0.05 | ||
| Smoking status | 0.277 | 0.451 | ||||
| Smoker | 2.20 (1.67, 2.9) | <0.001 | 2.15 (1.13, 4.09) | 0.019 | ||
| Non-smoker | 2.83 (2.02, 3.95) | <0.001 | 3.14 (1.52, 6.5) | 0.002 | ||
HRs were adjusted for age, sex, race/ethnicity, BMI, and smoking status. When analyzing age, adjustments were made for the other variables, and so on for subsequent analyses.