Table 3.
Association of collagen gene cluster expression and outcomes of BA patients after Kasai procedure
| COL6A1 | COL6A2 | COL6A3 | COL1A1 | |
|---|---|---|---|---|
| Cirrhosis (ΔCT ± SD) (n = 5) | 12.71 ± 4.02 | 9.76 ± 4.2 | 17.29 ± 9.44 | 2.46 ± 1.45 |
| Non-cirrhosis (ΔCT ± SD) (n = 15) | 7.51 ± 1.65 | 6.51 ± 2.18 | 9.74 ± 3.76 | 2.35 ± 0.84 |
| ΔΔCT (95% CI) | 5.2 (1.65–9.74) | 3.26 (0.01–6.5) | 7.55 (0.92–14.17) | 0.11 (− 1.52–1.74) |
| Fold change (2−ΔΔCT) | 36.63 | 9.55 | 187.04 | 1.08 |
| p-value | 0.0085* | 0.04* | 0.028* | 0.879 |
| Age at Kasai surgery ≥ 90 days (n = 15) | 10.34 ± 7.51 | 8.41 ± 2.9 | 12.2 ± 7.35 | 3.5 ± 1.78 |
| Age at Kasai surgery < 90 days (n = 5) | 10.25 ± 3.02 | 7.34 ± 4.82 | 10.85 ± 1.81 | 2.61 ± 1.16 |
| ΔΔCT (95% CI) | 0.09 (-7.31 – 7.48) | 1.07 (− 2.64 – 4.79) | 1.35 (− 7.97–10.67) | 2.9 (− 1.17–2.95) |
| Fold change (2−ΔΔCT) | 1.06 | 2.11 | 2.55 | 1.85 |
| p-value | 0.981 | 0.551 | 0.762 | 0.371 |
| Died (ΔCT ± SD) (n = 13) | 11.02 ± 4.68 | 8.66 ± 3.27 | 11.99 ± 4.84 | 3.4 ± 1.2 |
| Survived (ΔCT ± SD) (n = 7) | 9.1 ± 1.99 | 8.35 ± 2.42 | 8.27 ± 4.47 | 2.53 ± 1.94 |
| ΔΔCT (95% CI) | 1.92 (− 2.07–5.91) | 0.31 (− 2.75–3.37) | 3.72 (− 1.76–9.21) | 0.87 (− 1.33–3.07) |
| Fold change (2−ΔΔCT) | 3.78 | 1.24 | 13.21 | 1.83 |
| p-value | 0.323 | 0.832 | 0.168 | 0.409 |
*p < 0.05 was considered statistically significant