Table 4.
Biomechanical variables before and after interventions
| Overall (n = 80) |
SAVR (n = 40) |
TAVR (n = 40) |
P | |
|---|---|---|---|---|
| Pre-procedure strain variables | ||||
| GCS (%) | 5.2 [3.4,10.7] | 4.4 [3.3,5.3] | 10.7 [4.5,14.6] | < 0.001 |
| Pulse pressure-corrected strain (GCS/PP) | 9.1 [6.3,14.6] | 6.8 [5.5,9.2] | 13.6 [8.6,23.5] | < 0.001 |
| TTP (ms) | 300 [270,370.3] | 300 [270,334] | 315 [285,400] | 0.14 |
| ΔΑrea/TTP [cm2/s] | 1.7 [1.04,2.5] | 1.3 [0.9,1.9] | 2.2 [1.5,3.7] | 0.001 |
| Distensibility (10−3 mmHg) | 2 [1.3,4.2] | 1.5 [1.1,2.04] | 3.6 [1.9,6.7] | < 0.001 |
| FAC (%) | 10.7 [7.4,29.8] | 9.35 [6.8,11.9] | 30 [9.4,40.8] | < 0.001 |
| ESA (cm2) | 4.8 [3.8,5.7] | 5.3 [4.07,5.9] | 4.6 [3.7,5.6] | 0.12 |
| EDA (cm2) | 4.1 [3.1,5.3] | 4.8 [3.7,5.6] | 3.3 [2.6,4.9] | 0.002 |
| Post-procedure strain variables | ||||
| GCS (%) | 5.6 [4.1,16.23] | 4.65 [3.9,5.6] | 17 [6.1,20.9] | < 0.001 |
| Pulse pressure-corrected strain (GCS/PP %) | 10.8 [6.3,26.5] | 7.6 [6.1,10.8] | 26.8 [10.6,32] | < 0.001 |
| TTP (ms) | 263.5 [187.5,305] | 195 [166.8,250] | 300 [280,385] | < 0.001 |
| Δ Αrea/TTP [cm2/s] | 2.6 [1.8,3.6] | 2.5 [1.8,3.1] | 2.6 [1.8,4.2] | 0.26 |
| PP (mmHg) | 61 [47.8,72.3] | 60 [46.8,67.5] | 63 [50.8,77] | 0.08 |
| Distensibility (10−3 mmHg) | 1.6 [1.2,4.95] | 1.4 [1.1,1.7] | 4.9 [1.4,7.6] | < 0.001 |
| FAC (%) | 12.3 [9.5,35.2] | 10.5 [9.3,13.5] | 32.9 [10.3,57.1] | < 0.001 |
| ESA (cm2) | 4.6 [3.7,5.9] | 4.8 [4.1,6.0] | 4.3 [3.3,5.7] | 0.14 |
| EDA (cm2) | 3.9 [2.9,5] | 4.3 [3.6,5.4] | 3.3 [2.5,4.7] | 0.002 |
All values were (median [interquartile range])
cm Centimeters, EDA End diastolic area, ESA End systolic area, FAC Fractional area change, GCS Global circumferential strain [%], ms Milliseconds, PP Pulse pressure, SAVR Surgical aortic valve replacement, TAVR Transcatheter aortic valve replacement, TTP Time to peak