Table 2.

Univariate and multivariate-adjusted association of splenic area and overall survival in the discovery and validation cohort

Variable	Univariate analysis			Multivariate analysis (M1)1			Multivariate analysis (M2)2
	HR (95% CI)	P value		HR (95% CI)	P value		HR (95% CI)	P value
Discovery cohort
All patients
Normal	Ref			Ref			Ref
Abnormal	1.32(1.08,1.61)	0.007		1.29(1.06,1.58)	0.01		1.32(1.08,1.63)	0.008
Male
Normal	Ref			Ref			Ref
Abnormal	1.30 (1.01,1.67)	0.045		1.29 (1.00,1.67)	0.048		1.47 (1.13,1.93)	0.004
Female
Normal	Ref			Ref			Ref
Abnormal	1.18 (0.86,1.63)	0.31		1.17 (0.85,1.61)	0.35		1.07 (0.77,1.50)	0.69
Validation cohort
All patients
Normal	Ref			Ref			Ref
Abnormal	1.59 (1.01,2.50)	0.045		1.79 (1.12,2.86)	0.02		1.84 (1.12,3.02)	0.02
Male
Normal	Ref			Ref			Ref
Abnormal	1.54 (0.88–2.68)	0.13		1.5 (0.86,2.62)	0.15		1.57 (0.86,2.86)	0.14
Female
Normal	Ref			Ref			Ref
Abnormal	1.67 (0.75,3.74)	0.21		3.67(1.34,10.04)	0.01		3.83 (1.12,13.18)	0.03

Note:

¹Multivariate analysis (M1) was adjusted for age (continuous)

²Multivariate analysis (M2) was adjusted for multivariate analysis (M1) plus smoking history, preoperative CEA, tumor location, surgical approach, tumor differentiation, histologic stage and histologic type, pleural invasion and adjuvant chemotherapy