Table 5.

Delivered dose (DD, mg)/Loading dose (LD, mg) for adult breathing patterns. The DD/LD (%) values of the five nebulizers for the asthma adult breathing pattern decreased compared to those for the normal adult breathing pattern at all IgG concentrations

Breathing pattern	IgG conc. (mg/mL)	JN-PARIr (%)	JN-PARIb (%)	SMN-U150 (%)	VMN-SM1 (%)	VMN-SM3 (%)
ISO 27427	1	25.21 ± 1.75	24.31 ± 3.23	21.69 ± 1.05*	26.90 ± 1.82	0.278 ± 0.80
	10	26.11 ± 0.78*	23.89 ± 0.64*	21.92 ± 0.50*	27.11 ± 2.28	2.814 ± 0.63*
	20	26.96 ± 1.52*	25.99 ± 1.28*	23.64 ± 0.99*	29.47 ± 0.45*	7.426 ± 0.14*
	40	22.40 ± 2.19	24.33 ± 1.98*	23.85 ± 1.44*	25.25 ± 1.85	12.435 ± 0.24*
Normal adult	1	24.83 ± 1.13	23.77 ± 1.00	18.61 ± 0.57	28.80 ± 0.34	0.298 ± 1.25
	10	24.12 ± 0.47	20.13 ± 0.39	16.03 ± 0.73	26.30 ± 1.04	2.538 ± 0.65
	20	19.97 ± 0.26	17.99 ± 0.67	16.65 ± 0.60	21.71 ± 0.28	5.647 ± 0.45
	40	21.53 ± 0.42	15.73 ± 0.34	17.40 ± 0.68	22.61 ± 1.00	10.651 ± 0.44
Asthma adult	1	17.71 ± 1.10*	16.74 ± 0.86*	15.21 ± 1.28*	23.53 ± 1.08*	0.239 ± 0.52*
	10	14.41 ± 0.20*	13.19 ± 0.93*	12.00 ± 0.57*	15.49 ± 0.26*	1.797 ± 0.40*
	20	16.02 ± 1.31*	15.02 ± 1.14*	11.94 ± 0.44*	18.58 ± 0.30*	4.392 ± 0.32*
	40	14.78 ± 0.54*	12.82 ± 0.73*	11.61 ± 0.32*	15.69 ± 0.27*	6.821 ± 0.72*

All data are presented as the mean ± SD values. * p < 0.05, versus the normal adult pattern