Table 4.
Performance levels of RDTs evaluated against TTBS and PCR for the detection of Plasmodium falciparum
| Advantage Malaria P.f. card® | Advantage Malaria Pan + Pf Card® | |
|---|---|---|
| Microscopy as reference method | ||
| Low parasitemiaa | ||
| SEb [95% CI] | 88.7 [81.9–93.2] | 87.9 [81.1–92.7] |
| PPVb [95% CI] | 94.0 [88.8–96.9] | 93.9 [88.7–96.8] |
| High parasitemiaa | ||
| SEb [95% CI] | 97.4 [90.2–99.6] | 97.4 [90.2–99.6] |
| PPV [95% CI] | 89.4 [81.7–94.1] | 89.4 [81.7–94.1] |
| Total | ||
| SE [95% CI] | 91.8 [87.1–94.9] | 91.3 [86.6–94.6] |
| SPb [95% CI] | 94.7 [90.0–97.4] | 94.7 [90.0–97.4] |
| PPV [95% CI] | 95.7 [92.2–97.7] | 95.7 [92.2–97.7] |
| NPVb [95% CI] | 90.0 [85.2–93.3] | 89.5 [84.7–92.9] |
| PCR as reference method | ||
| SE [95% CI] | 84.2 [84.7–92.8] | 83.8 [78.5–88.2] |
| SP [95% CI] | 96.5 [92.0–98.9] | 96.5 [92.0–98.9] |
| PPV [95% CI] | 97.6 [94.4–99.0] | 97.6 [94.4–99.0] |
| NPV [95% CI] | 78.4 [71.5–84.1] | 78.0 [71.0–83.6] |
aLow parasitemia = 50–100 asexual parasitemia/µl, high parasitemia = 2000–10000 asexual parasitemia/µl
bSE = sensitivity, SP = specificity; PPV = positive predictive value; NPV = negative predictive value