Table 2.
GO terms associated with fibrosis and inflammation in transcriptomics analysis
| Class | GO term | Gene up | Gene down | Rich factor | Pvalue | Qvalue |
|---|---|---|---|---|---|---|
| Fibrotic process | microfibril | Mfap5, Ltbp1, Mfap4, Mfap2 | 30.39 | 2.23E-06 | 1.70E-04 | |
| collagen-activated signaling pathway | Col1a1, Col4a5, Ddr2, Itga11 | Ubash3b, Oscar | 27.35 | 3.64E-08 | 8.45E-06 | |
| collagen-activated tyrosine kinase receptor signaling pathway | Col1a1, Col4a5, Ddr2 | Ubash3b | 22.80 | 6.66E-06 | 3.52E-04 | |
| collagen trimer | Col4a5, C1qtnf5, Col6a1, Cthrc1, C1qtnf6, Col1a1, Col6a2, Col14a1 | Fcnb | 14.55 | 1.36E-09 | 7.10E-07 | |
| collagen catabolic process | Mrc2, Mmp2, Ctsk, Mmp14 | 12.43 | 7.70E-05 | 2.05E-03 | ||
| collagen binding | Aspnl1, Aspn, Antxr1, Mrc2, Ctsk, Col6a2, Itga11, Lum, Ddr2, Col6a1 | 12.00 | 8.02E-09 | 3.05E-06 | ||
| collagen-containing extracellular matrix |
Ssc5d, Lum, Col6a2, Gpc1, Eln, Thbs4, Ntn4, Col1a1, LOC102553715, Adamtsl4, Hmcn1, Tgfb3, Col14a1, LOC103690116, Col6a1, Timp3, Ltbp1, Smoc1, Adamts2, Mfap4, Angptl1, Lama2, Ecm1, Matn4, Fbln2, Col4a5, Bmp7, Postn |
Timp1, Serpine1, Fcnb, Rarres2 | 11.46 | 8.21E-23 | 1.14E-19 | |
| extracellular matrix binding | Ecm1, Gpc1, Ssc5d, Smoc1, Ntn4, Fbln2, Eln, LOC100911932 | 11.40 | 2.58E-07 | 3.72E-05 | ||
| Inflammatory process | chemokine activity | Cxcl13, Ccl5, Ccl21 | Cxcl1, Ccl7, Cxcl6 | 11.40 | 5.28E-06 | 2.94E-04 |
| regulation of monocyte chemotaxis | Ccl5, Nbl1 | Serpine1, Pla2g7 | 11.40 | 1.11E-04 | 2.54E-03 | |
| positive regulation of macrophage migration | Mdk, Mmp14, Il34 | Rarres2 | 10.52 | 1.55E-04 | 3.26E-03 |