Table 2.

Metabolites changed in intrahepatic cholestasis of pregnancy (ICP) urine specimens (positive ion mode)

Name	VIP	P-value	Fold change
Acetylproline	2.528	0.001	32.157
N-Acetylmannosamine	1.839	0.009	7.482
3-oxo lithocholic acid	2.324	0.001	5.429
19(R)-hydroxy Prostaglandin A2	1.598	0.036	3.736
Threonine	1.778	0.022	3.635
1-Aminocyclopropanecarboxylate	1.639	0.047	2.726
17-alpha-Hydroxyprogesterone	1.627	0.045	2.415
Methionine sulfoxide	1.360	0.037	1.368
Indole-3-carboxylic acid	1.434	0.025	0.749
Adenine	1.494	0.007	0.714
2,4-Dihydroxy-butanoic acid	1.371	0.032	0.708
cytosine	1.282	0.038	0.696
Uracil	1.513	0.044	0.693
Indole	1.386	0.033	0.689
N-alpha-Acetyl-L-lysine	1.728	0.015	0.686
3-Methyladenine	1.544	0.013	0.657
Testosterone	1.517	0.045	0.642
N,N-Dimethylarginine	1.804	0.008	0.636
Creatine	1.570	0.010	0.634
Creatinine	1.732	0.002	0.630
Glycylproline	1.684	0.017	0.601
4-PREGNEN-20-ALPHA-OL-3-ONE	1.378	0.040	0.587
3-Hydroxypropionic acid	1.456	0.034	0.585
Guanidinoacetate	1.650	0.020	0.568
Indolelactic acid	1.467	0.021	0.557
Estrone	1.361	0.048	0.544
3-Hydroxyphenylacetic acid	1.628	0.020	0.537
p-Benzoquinone	1.532	0.017	0.521
1-Methylnicotinamide	1.320	0.030	0.460
5,6-Dihydrouracil	2.123	0.002	0.460
Trigonelline	1.521	0.034	0.433
Androstenedione	1.804	0.004	0.428
Androsterone	1.647	0.009	0.405
p-Coumaric acid	1.732	0.001	0.310
Mono-iso-butyl phthalate	1.472	0.039	0.299
Cyclo-prolylglycine	1.741	0.026	0.272

VIP, the variable importance in the projection; Fold change, the ratio of ICP/CON.