Table 3.

Metabolites changed in intrahepatic cholestasis of pregnancy (ICP) urine specimens (negative ion mode)

Name	VIP	P-value	Fold change
Sulfochenodeoxycholic acid	2.484	0.008	242.582
Cholic acid	2.254	0.009	55.967
Glycochenodeoxycholic acid	1.461	0.043	8.302
Taurocholic acid	1.697	0.045	8.039
Glycocholic acid	1.849	0.006	3.720
L-Glutamic acid	1.340	0.029	0.844
2-Oxoadipate	1.400	0.031	0.738
N-Acetylglutamic acid	1.399	0.047	0.709
L-Pyroglutamic acid	1.465	0.021	0.687
L-Threonic acid	1.710	0.004	0.674
Xanthosine	1.328	0.047	0.673
N2-Methylguanosine	1.536	0.016	0.636
Mevalonic acid	1.380	0.019	0.622
Geranic acid	1.543	0.043	0.606
L-Histidine	1.401	0.041	0.598
Imidazoleacetic acid	1.636	0.035	0.559
DL-4-Hydroxy-3-methoxymandelic acid	1.447	0.039	0.555
N-Methylleucine	1.745	0.028	0.553
3-Methoxyphenylacetic acid	1.498	0.047	0.524
Ethylmalonic acid	1.634	0.032	0.509
Perillic acid	1.762	0.008	0.463
D-Glutamine	1.662	0.029	0.450
2,3-dinor Prostaglandin E1	2.238	0.000	0.434
Glycyl-L-leucine	1.645	0.018	0.432
Uracil	1.800	0.002	0.390
N-acetyltryptophan	1.252	0.033	0.359
Hydroxyphenyllactic acid	1.737	0.023	0.355
Nonanoic acid	1.763	0.033	0.284

VIP, the variable importance in the projection; Fold change, the ratio of ICP/CON.