Table 5.
Potential diagnostic biomarkers for ICP in targeted metabolomics
| Metabolite | Ave (ICP)/(ng/mL) | Ave (CON)/(ng/mL) | Fold change | P-value |
|---|---|---|---|---|
| 3-hydroxypropionic acid | 15732.548 | 47372.174 | 0.332 | 0.0004 |
| Uracil | 1793.620 | 3950.872 | 0.454 | 0.0031 |
| Glycolic acid | 29776.145 | 61405.950 | 0.485 | 0.0144 |
| L-malic acid | 1034.511 | 2442.886 | 0.423 | 0.0340 |
| DL-pyroglutamic acid | 37181.635 | 72246.583 | 0.515 | 0.0310 |
| L-4-hydroxyproline | 1360.906 | 2802.899 | 0.486 | 0.0362 |
| L-phenylalanine | 1128.042 | 2467.921 | 0.457 | 0.0018 |
| cis-aconitate | 49167.892 | 98772.967 | 0.498 | 0.0293 |
| Citric acid | 66582.475 | 141568.053 | 0.470 | 0.0069 |
| Homogentisic acid | 46.536 | 120.449 | 0.386 | 0.0245 |
| 3-(4-Hydroxyphenyl)lactate | 298.919 | 582.549 | 0.513 | 0.0125 |
| Palmitic acid | 467.207 | 1113.219 | 0.420 | 0.0223 |
| Linoleic acid | 74.395 | 195.675 | 0.380 | 0.0043 |
Ave (ICP), the average concentrations of metabolites in ten urine specimens from ICP pregnant women; Ave (CON), the average concentrations of metabolites in ten urine specimens from healthy pregnant women; Fold change, the ratio of Ave (ICP)/Ave (CON); ICP, intrahepatic cholestasis of pregnancy; CON, the control group