Table 4.
Univariate and multivariate analyses of overall survival for 498 CUP patients
| Characteristics | Patients N (%) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Median Survival (Month) | p value | Hazard Ratio (95% CI) | p value | ||
| Age | |||||
| ≤ 57 | 228 | 21 | < 0.001 | 0.646 (0.509─0.819) | < 0.001 |
| > 57 | 270 | 10 | Reference | ||
| Gender | |||||
| Female | 222 | 18 | 0.061 | ||
| Male | 276 | 12 | |||
| Number of metastatic sites | |||||
| < 3 | 151 | < 0.001 | 0.777 (0.661─0.914) | 0.002 | |
| ≥ 3 | 347 | Reference | |||
| Histology | |||||
| Squamous cell carcinoma | 96 | 22 | 0.015 | 1.017 (0.736─1.405) | 0.918 |
| Other | 402 | 12 | Reference | ||
| Disease subgroup | |||||
| Favorable | 95 | / | < 0.001 | 0.744 (0.511─1.083) | 0.122 |
| Unfavorable | 403 | 12 | Reference | ||
| Bone metastasis | |||||
| Present | 132 | 6 | < 0.001 | 1.605 (1.241─2.075) | < 0.001 |
| Absent | 366 | 20 | Reference | ||
| Liver metastasis | |||||
| Present | 75 | 8 | < 0.001 | 1.456 (1.082─1.960) | 0.013 |
| Absent | 423 | 17 | Reference | ||
| Lung metastasis | |||||
| Present | 109 | 11 | < 0.001 | 1.323 (1.018─1.720) | 0.037 |
| Absent | 389 | 16 | Reference | ||
| CK7 expression (N = 359) | |||||
| Positive | 264 | 14 | 0.896 | ||
| Negative | 95 | 11 | |||
| CK20 expression (N = 290) | |||||
| Positive | 57 | 10 | 0.249 | ||
| Negative | 233 | 12 | |||
| Result of Canhelp-Origin molecular testing (N = 300) | |||||
| Predictable | 213 | 30 | < 0.001 | ||
| Unpredictable | 87 | 7 | |||
| Predicted site of Canhelp-Origin molecular testing (N = 213) | |||||
| Breast | 48 | / | 0.009 | ||
| Other | 165 | 22 | |||
| Treatment (N = 394) | |||||
| Site-specific treatment | 229 | 19 | < 0.001 | ||
| Empiric chemotherapy | 137 | 15 | |||
| Palliative care | 28 | 3 | |||