FIG. 4.

Cross-adaptation to other stresses indicates overlapping response systems. (A) Adaptation of wild-type cells to a lethal dose of LoaOOH (0.2 mM; 1 h) following pretreatment with a sublethal dose of MDA (1 mM; 1 h). (B) Adaptation of wild-type cells to a lethal dose of LoaOOH (0.2 mM; 1 h) following pretreatment with a mild heat shock (37°C; 1 h). (C) Fold adaptation, following pretreatment with a sublethal dose of LoaOOH (0.05 mM; 1 h), to the organic hydroperoxides cumene hydroperoxide (COOH; 4 mM) and tert-butyl hydroperoxide (tBOOH; 12 mM), the superoxide-generating agents paraquat (PQ; 15 mM) and menadione (MD; 6 mM), MDA (5 mM), and H₂O₂ (5 mM). An asterisk indicates that no adaptive response was detected. Data are means of triplicates from a representative experiment.