Table 2.
Association of lipid biomarkers with baseline CAC.
| Agatston Score | Volume Score | Density Score | |||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P | |
| Lp(a) | 1.04 | 0.98, 1.10 | 0.237 | 1.04 | 0.98, 1.11 | 0.176 | 1.04 | 0.95, 1.15 | 0.365 |
| Lp(a) with adjustment for HDL-C and TG | 1.05 | 0.99, 1.11 | 0.140 | 1.05 | 0.99, 1.12 | 0.095 | 1.04 | 0.95, 1.15 | 0.374 |
| LDL-C | 1.26 | 1.19, 1.33 | <0.001 | 1.26 | 1.19, 1.33 | <0.001 | 0.91 | 0.83, 0.99 | 0.030 |
| LDL-C with adjustment for HDL-C and TG | 1.25 | 1.18, 1.32 | <0.001 | 1.25 | 1.18, 1.32 | <0.001 | 0.91 | 0.83, 0.99 | 0.031 |
| HDL-C | 0.85 | 0.80, 0.90 | <0.001 | 0.84 | 0.79, 0.89 | <0.001 | 1.03 | 0.94, 1.13 | 0.551 |
| TG | 1.11 | 1.05, 1.18 | <0.001 | 1.13 | 1.06, 1.20 | <0.001 | 0.98 | 0.89, 1.07 | 0.663 |
| Total cholesterol | 1.22 | 1.15, 1.29 | <0.001 | 1.22 | 1.15, 1.29 | <0.001 | 0.90 | 0.83, 0.99 | 0.028 |
| apoB (n=4,582) | 1.24 | 1.16, 1.33 | <0.001 | 1.25 | 1.17, 1.34 | <0.001 | 0.92 | 0.83, 1.01 | 0.082 |
| Non-HDL-C | 1.28 | 1.21, 1.36 | <0.001 | 1.29 | 1.22, 1.37 | <0.001 | 0.90 | 0.82, 0.99 | 0.025 |
All lipid biomarkers were ln-transformed. OR are presented per standard deviation. Models included individual biomarkers + CVD risk factors (age, sex, race/ethnicity, SBP, DM, smoking, hypertension treatment); For Lp(a) and LDL-C, models with additional adjustment for HDL-C and TG are shown. Models for density are adjusted for volume. Abbreviations: ApoB, apolipoprotein B; CAC, coronary artery calcium; CI, confidence interval; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; Lp(a), lipoprotein (a); OR, odds ratio; TG, triglycerides.