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. 2023 Nov 10;11(1):e200172. doi: 10.1212/NXI.0000000000200172

Figure 2. CD69+CD103+ Trm-like Cells Are Abundant in the CSF.

Figure 2

(A) The frequency of CD69+CD103+CD8+ Trm-like cells is not different in the peripheral blood from patients with MS and NMOSD compared with that in controls. (B) The frequency of CD69+CD103+CD4+ Trm-like cells is not different in the peripheral blood from patients with MS and NMOSD compared with that in controls. (C) Representative flow cytometry panels showing CD69+CD103+ Trm-like population among memory CD8+ T cells. (D) The frequency of CD69+CD103+ Trm-like cells is higher in the CSF than in the peripheral blood among memory CD8 T cells. The samples were from 4 patients with MS, and 1with NMOSD. None of them were in a relapse state. Data are mean ± SD; One-way ANOVA with the Holm-Sidak multiple comparisons test with HC as a control (A, B) and paired t test (D). HC = healthy control; NMOSD = neuromyelitis optica spectrum disorder; PB = peripheral blood; RRMS = relapsing-remitting MS; SPMS = secondary progressive MS.