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. 2023 Nov 10;11(1):e200172. doi: 10.1212/NXI.0000000000200172

Figure 4. CD8+ Trm-like Cells Are Increased in the CSF in Chronic Inflammatory and Neurodegenerative Diseases.

Figure 4

(A) The frequency of CD69+CD103+CD8+ T cells is increased in the CSF in chronic inflammatory conditions, PD, and AD. The samples were analyzed in Kyoto University for the left 6 categories and in National Center of Neurology and Psychiatry for the right MS category (MS*). All 4 patients in MS* category were not in a relapse state. One with RRMS, 2 with SPMS, and 1 with PPMS. (B) CD4+ Trm-like cells were analyzed in the same way as in (A). (C) The frequency of CD69+CD103+ DP population among memory CD8+ T cells and the total cell number in the CSF. The total cell count was not determined between 1 and 10/µL in the clinical laboratory in the facility. The count in this range is described as 5/µL in the plot. (D) The frequency of CD69+CD103+ DP population among memory CD8+ T cells and the age of the patients. Data are mean ± SD; One-way ANOVA with the Holm-Sidak multiple comparisons test with HC as a control (A, B). AD = Alzheimer disease; ALS = amyotrophic lateral sclerosis; PB = peripheral blood; PD = Parkinson disease.