Figure 5. CD69⁺CD103⁺ DP CD8⁺ T Cells From Patients With MS Have a Phenotype Closer to Trm Compared With Those From HC.

(A) Temporal alteration of the frequency of CD8⁺ Trm-like cells during the recovery period of acute inflammatory diseases. (B) Temporal alteration of the frequency of CD4⁺ Trm-like cells during the recovery period of acute inflammatory diseases. (C) Gene expressions in CD69⁺CD103⁺ DP CD8⁺ T cells in the CSF are analyzed using public single-cell RNA sequencing dataset.³ Three CD8⁺ T-cell populations are shown; CD69⁺CD103⁺ DP in the CSF, non-DP in the CSF, and total CD8⁺ T cells in the peripheral blood, from patients with MS. The sum of expressions for each gene in each condition are normalized to 1. (D) CD8⁺ T cells from patients with a noninflammatory condition (intracranial idiopathic hypertension) were analyzed in the same way as in (C). PB = peripheral blood.