Table 2.
Downregulated Probes (Expression Ratio <0.5) in NMOSD After 1 Year Treatment of TCZ, Which Showed Significant Upregulation Before TCZ Treatment Compared With HCs
| Probe name | Gene name (gene symbol) | Description | Expression ratio (post-TCZ (12 m)/pre-TCZ) | Expression ratio (pre-TCZ/HC) |
| A_23_P140384 | Cathepsin G (CTSG) | Homo sapiens cathepsin G (CTSG), mRNA [NM_001911] | 0.102 | 11.566 |
| A_23_P326080 | Defensin, alpha 4, corticostatin (DEFA4) | Homo sapiens defensin, alpha 4, corticostatin (DEFA4), mRNA [NM_001925] | 0.139 | 14.410 |
| A_33_P3279353 | Azurocidin 1 (AZU1) | Homo sapiens azurocidin 1 (AZU1), mRNA [NM_001700] | 0.143 | 9.705 |
| A_23_P131785 | Bactericidal/permeability-increasing protein (BPI) | Homo sapiens bactericidal/permeability-increasing protein (BPI), mRNA [NM_001725] | 0.144 | 5.567 |
| A_23_P130961 | Elastase, neutrophil expressed (ELANE) | Homo sapiens elastase, neutrophil expressed (ELANE), mRNA [NM_001972] | 0.147 | 12.664 |
| A_23_P166848 | Lactotransferrin (LTF) | Homo sapiens lactotransferrin (LTF), transcript variant 1, mRNA [NM_002343] | 0.223 | 5.936 |
| A_23_P31816 | Defensin, alpha 3, neutrophil-specific (DEFA3) | Homo sapiens defensin, alpha 3, neutrophil-specific (DEFA3), mRNA [NM_005217] | 0.276 | 7.789 |
| A_23_P169437 | Lipocalin 2 (LCN2) | Homo sapiens lipocalin 2 (LCN2), mRNA [NM_005564] | 0.277 | 5.934 |
| A_23_P253791 | Cathelicidin antimicrobial peptide (CAMP) | Homo sapiens cathelicidin antimicrobial peptide (CAMP), mRNA [NM_004345] | 0.319 | 9.094 |
| A_33_P3407529 | Proline-rich transmembrane protein 4 (PRRT4) | Homo sapiens proline-rich transmembrane protein 4 (PRRT4), transcript variant 1, mRNA [NM_001174164] | 0.338 | 4.087 |
| A_23_P206760 | Haptoglobin (HP) | Homo sapiens haptoglobin (HP), transcript variant 1, mRNA [NM_005143] | 0.487 | 4.482 |