Table 3.
Findings of Studies Reporting Neuropsychological Testing in Patients With Anti-CASPR2, Anti-GAD65, and Anti-GABAB-R AE
| Domain/test | Antibody, N | Studies | Summary of findings |
| Memory | |||
| Word list | CASPR2 = 8 GABAB-R = 5 GAD65 = 33 |
7 |
C: GABAB-R: N.d. I: CASPR2: 0% (z < −1 or −1.5) Summary; GAD65: 11% (z < −1) to 71% (z < −1.5) Summary; 20% any parameter (z < −1) |
| DCS | CASPR2 = 8 GAD65 = 31 |
4 |
I: CASPR2: 0% (z < −1.5) to 67% (z < −1) Summary I: GAD65: 37% (z < −1.5) to 57% (z < −1) Summary; 60% any parameter (z < −1) |
| BVMT | GABAB-R = 10 | 1 | I: GABAB-R: 60% |
| AFLT | GABAB-R = 5 | 1 | C: N.d. |
| Attention | |||
| Digit span | GABAB-R = 5 | 1 | C: N.d. |
| Block tapping | GABAB-R = 10 | 1 | I: GABAB-R: 50% |
| Sustained attention | GABAB-R = 10 | 1 | I: GABAB-R: 30% |
| Processing speed | |||
| Coding | GABAB-R = 5 | 1 | C: N.d. |
| Visuospatial | |||
| Visuoconstruction | GABAB-R = 5 | 1 | C: N.d. |
| Language | |||
| Fluency-semantic | GABAB-R = 5 | 1 | C: N.d. |
| Executive | |||
| Stroop inhibition | GABAB-R = 5 | 1 | C: N.d. |
| Reasoning | GABAB-R = 10 | 1 | I: GABAB-R: 50% |
Abbreviations: AFLT = Aggies figures learning test; BVMT = brief visuospatial memory test; C = comparison to Controls; CASPR2 = Contactin-associated protein-like 2; DCS = Diagnosticum für Cerebralschädigung; GABAB-R = G-protein coupled receptors for gamma-aminobutyric acid (B); GAD65 = Glutamic acid decarboxylase (65-kd isoform); I = Normative Impairment; N.d. = no difference.
Normative Impairment reported using a cut-off score of z < −1.5 unless otherwise specified; Total Studies indicates the total number of studies reporting each test; n indicates the total number of patients included in the synthesis and is the sum of the patients in the nonoverlapping samples.