Table 4.
Total error rate of misclassification of disease-causing and neutral variation when each feature was assessed by itself in the logistic regression analysis
| Feature | Error rate (%) |
|---|---|
| SIFT conservation score | 18.41 |
| Normalized site entropy | 18.60 |
| Change in residue frequency | 19.92 |
| BLOSUM62 score | 27.70 |
| GRANTHAM score | 31.31 |
| Change in volume | 34.91 |
| Change in hydrophobicity | 37.95 |
| Location of variation (i.e. TM or non-TM) | 39.47 |
| BLOSUM62 score (TM only) | 22.53 |
| PHAT (TM only) | 24.90 |
| Change in free energy of hydropathy (TM only) | 27.27 |
Here, phylogenetic features refer to SIFT score, normalized site entropy and change in residue frequency.