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. 2023 Dec 1;4(6):e439. doi: 10.1002/mco2.439

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© 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Usp22 accelerates c‐Myc/NrasGV12‐induced hepatocarcinogenesis. (A) Study design (created with BioRender.com). C57BL/6J mice were grouped as G1, G2, G3, and G4. (B) Survival curves of G1 (n = 7) and G2 (n = 9). Usp22 overexpression shortened the survival time of mice (p = 0.0239). (C) Survival curves of G3 (n = 5) and G4 (n = 6). Usp22 ablation prolongs the survival time of mice (p = 0.0018). (D) Representative images of gross liver specimens, hematoxylin–eosin (HE), Flag‐tag, and Ki‐67 staining in the G1 and G2 groups. (E) Representative images of gross liver specimens, HE, and Ki‐67 staining in the G3 and G4 groups. (F) The weight of livers in each group (^* p < 0.05).