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. 2023 Dec 1;4(6):e439. doi: 10.1002/mco2.439

FIGURE 7.

FIGURE 7

Clinical significance of USP22 in patients with hepatocellular carcinoma (HCC) after liver transplantation (LT). (A) Different expression levels of USP22 and FKBP12 detected using immunohistochemical staining in two LT recipients diagnosed with HCC. (B) Positive correlation between USP22 and FKBP12 expression in 205 HCC tissues (R 2 = 0.3609, p < 0.0001). (C) The effect of USP22 on the overall survival (OS) of LT recipients with HCC exceeding the Milan Criteria evaluated using the Kaplan–Meier method (n = 115, p = 0.027). (D) The effect of sirolimus (SRL) on the OS of recipients with high USP22 expression assessed using the Kaplan–Meier method (n = 68, p = 0.012). (E) The effect of SRL on the OS of recipients with low USP22 expression shown using the Kaplan–Meier method (n = 47, p = 0.465). (F) Diagram of the molecular mechanisms of USP22, FKBP12, mTORC1, and autophagy in HCC.