Table 2.
MR analysis between gut microbiota and multiple gastrointestinal diseases with horizontal pleiotropy and heterogeneity tests.
| Outcome | Exposure | SNP | IVW (95%CI) | P_IVW | MR.Egger | SE | P_MR-Egger | Cochran’s Q | P_Cochran’s Q |
|---|---|---|---|---|---|---|---|---|---|
| CD | DefluviitaleaceaeUCG011 | 9 | 1.2667 (1.0301–1.5576) | 0.0250 | 0.0047 | 0.0376 | 0.9049 | 3.4118 | 0.9059 |
| FamilyXIIIUCG001 | 8 | 1.3154(1.0079–1.7168) | 0.0436 | 0.0292 | 0.0320 | 0.3967 | 3.6577 | 0.8183 | |
| Odoribacter | 7 | 1.5146(1.0930–2.0987) | 0.0126 | 0.0061 | 0.0393 | 0.8821 | 3.1538 | 0.7893 | |
| Oxalobacter | 11 | 1.2920(1.1265–1.4819) | 0.0003 | 0.0124 | 0.0221 | 0.5852 | 8.3663 | 0.5931 | |
| Parasutterella | 15 | 1.2312(1.0261–1.4774) | 0.0253 | 0.0124 | 0.0221 | 0.5852 | 13.3606 | 0.3434 | |
| RikenellaceaeRC9gutproup | 11 | 1.1674(1.0055–1.3553) | 0.0422 | 0.0144 | 0.0230 | 0.5397 | 13.8975 | 0.1777 | |
| RuminococcaceaeUCG014 | 11 | 1.4030(1.1052–1.7811) | 0.0054 | 0.0032 | 0.0271 | 0.9096 | 4.0714 | 0.9441 | |
| NB1n | 13 | 1.1768(1.0248–1.3513) | 0.0211 | 0.0183 | 0.0330 | 0.5906 | 12.3296 | 0.4196 | |
| Bifidobacteriaceae | 12 | 0.7530(0.5801–0.9773) | 0.0330 | 0.0494 | 0.0288 | 0.1168 | 14.4076 | 0.2113 | |
| Prevotellaceae | 16 | 0.8004(0.6418–0.9981) | 0.0481 | 0.0214 | 0.0278 | 0.4536 | 17.9568 | 0.2649 | |
| Butyrivibrio | 15 | 0.8609(0.7724–0.9596) | 0.0068 | 0.0328 | 0.0356 | 0.3739 | 8.3393 | 0.8709 | |
| LachnospiraceaeUCG001 | 12 | 0.7811(0.6370–0.9577) | 0.0175 | 0.0329 | 0.0436 | 0.4678 | 9.2915 | 0.5950 | |
| RuminococcaceaeUCG009 | 11 | 0.7739(0.6432–0.9311) | 0.0066 | 0.0052 | 0.0377 | 0.8939 | 8.0467 | 0.6243 | |
| Bifidobacteriales | 12 | 0.7530(0.5801–0.9773) | 0.0330 | 0.0494 | 0.0288 | 0.1168 | 14.4076 | 0.2113 | |
| UC | Lentisphaeria | 8 | 0.8254(0.7058–0.9652) | 0.0162 | 0.0384 | 0.0396 | 0.3691 | 6.3991 | 0.4940 |
| Peptococcaceae | 9 | 0.8137(0.6735–0.9831) | 0.0326 | 0.0074 | 0.0225 | 0.7514 | 6.3662 | 0.6063 | |
| Eubacteriumventriosumgroup | 15 | 0.7267(0.5609–0.9415) | 0.0157 | 0.0363 | 0.0434 | 0.4180 | 20.4377 | 0.0848 | |
| Clostridiumsensustricto | 7 | 0.7413(0.5521–0.9954) | 0.0465 | 0.0138 | 0.0387 | 0.7355 | 8.7890 | 0.1178 | |
| Eubacteriumeligensgroup | 7 | 1.4872(1.0984–2.0135) | 0.0102 | 0.0165 | 0.0490 | 0.7500 | 1.7731 | 0.9393 | |
| LachnospiraceaeFCS020group | 12 | 1.3621(1.0934–1.6968) | 0.0058 | 0.0363 | 0.0190 | 0.0850 | 13.4685 | 0.2638 | |
| LachnospiraceaeUCG008 | 11 | 1.1908(1.0156–1.3962) | 0.0315 | 0.0159 | 0.0428 | 0.7187 | 4.2360 | 0.9361 | |
| GERD | Bacteroidia | 4 | 1.105(1.0004–1.2206) | 0.0490 | 0.0102 | 0.0145 | 0.5553 | 1.9847 | 0.5756 |
| Mollicutes | 3 | 1.1148(1.0141–1.2254) | 0.0244 | 0.0463 | 0.0299 | 0.3649 | 2.4684 | 0.2911 | |
| Bacteroidaceae | 2 | 1.2096(1.0333–1.4159) | 0.0179 | NA | NA | NA | 1.5701 | 0.2102 | |
| Christensenellaceae | 5 | 0.9131(0.8449–0.9868) | 0.0217 | 0.0039 | 0.0060 | 0.5635 | 2.3441 | 0.6727 | |
| IBS | Christensenellaceae | 6 | 0.9968(0.9943–0.9994) | 0.0142 | 0.0005 | 0.0005 | 0.4416 | 1.5216 | 0.9106 |
| Clostridiaceae1 | 6 | 0.9967(0.9944–0.9991) | 0.0013 | 0.0002 | 0.0005 | 0.7131 | 3.1394 | 0.6785 | |
| Lactobacillaceae | 4 | 0.9977(0.9957–0.9997) | 0.0249 | 0.0005 | 0.0009 | 0.6448 | 0.8622 | 0.8345 | |
| Clostridiumsensustricto1 | 2 | 0.9946(0.9907–0.9985) | 0.0071 | NA | NA | NA | 0.0782 | 0.7797 | |
| RuminococcaceaeUCG004 | 9 | 0.9983(0.9967–0.9999) | 0.0420 | 0.0003 | 0.0007 | 0.6967 | 2.8072 | 0.9459 | |
| RuminococcaceaeUCG009 | 8 | 0.9979(0.9964–0.9994) | 0.0053 | 0.0001 | 0.0008 | 0.9449 | 2.1877 | 0.9487 | |
| Bacilli | 10 | 1.0026(1.0002–1.0049) | 0.0325 | 0.0004 | 0.0007 | 0.5374 | 12.7021 | 0.1766 | |
| Prevotella7 | 9 | 1.0011(1.0002–1.0021) | 0.0191 | 0.0003 | 0.0006 | 0.6164 | 4.3770 | 0.8216 | |
| GC | Genus Eubacteriumbrachygroup | 10 | 1.2067(1.0743–1.3553) | 0.0015 | −0.0625 | 0.0374 | 0.1332 | 8.4782 | 0.4868 |
| Genus Roseburia | 13 | 1.3416 (1.0706–1.6811) | 0.0107 | 0.0202 | 0.03244 | 0.5470 | 17.4119 | 0.1347 | |
| Family FamilyXI | 8 | 1.1323 (1.0121–1.2668) | 0.0300 | −0.0558 | 0.0496 | 0.3029 | 8.8383 | 0.2645 | |
| Genus Clostridiumsensustricto1 | 7 | 0.5401(0.3542–0.8235) | 0.0042 | 0.0822 | 0.0500 | 0.1612 | 28.4135 | 0.0001 | |
| Order Actinomycetales | 5 | 0.7558 (0.6130–0.9319) | 0.0088 | −0.0185 | 0.0427 | 0.6933 | 4.2023 | 0.3793 | |
| Family Actinomycetaceae | 5 | 0.7562 (0.6134–0.9322) | 0.0089 | −0.0187 | 0.0427 | 0.6907 | 4.2088 | 0.3785 | |
| Family Rikenellaceae | 19 | 0.8634 (0.7465–0.9986) | 0.0479 | −0.0257 | 0.0201 | 0.2179 | 16.5467 | 0.5544 | |
| Class Negativicutes | 12 | 0.8159 (0.6658–0.9999) | 0.0499 | −0.0094 | 0.0306 | 0.7638 | 9.5637 | 0.5700 | |
| Order Selenomonadales | 12 | 0.8159 (0.6658–0.9999) | 0.0499 | −0.0094 | 0.0306 | 0.7638 | 9.5637 | 0.5700 | |
| CRC | Genus Prevotella7 | 11 | 1.0994 (1.0284–1.1754) | 0.005411729 | 0.0429 | 0.0316 | 0.2085 | 9.0324 | 0.5290 |
| Genus Eubacteriumbrachygroup | 10 | 1.1234 (1.0337–1.2209) | 0.006143512 | 0.0064 | 0.0242 | 0.7968 | 9.2300 | 0.4163 | |
| Genus RuminococcaceaeUCG004 | 11 | 1.1555 (1.0227–1.3054) | 0.020290316 | −0.0251 | 0.0311 | 0.4405 | 10.9638 | 0.3603 | |
| Genus Anaerostipes | 13 | 1.1965(1.0191–1.4048) | 0.028441144 | 0.0241 | 0.0187 | 0.2246 | 13.9720 | 0.3025 | |
| Genus RuminococcaceaeUCG011 | 8 | 1.0946(1.0074–1.1893) | 0.032776792 | 0.0177 | 0.0286 | 0.5580 | 6.8197 | 0.4479 | |
| Genus Eubacteriumxylanophilumgroup | 9 | 0.7877 (0.6762–0.9176) | 0.002181713 | −0.0270 | 0.0208 | 0.2343 | 5.7364 | 0.6767 | |
| Order Bacillales | 9 | 0.9122 (0.8478–0.9816) | 0.013997148 | −0.0196 | 0.0230 | 0.4238 | 3.9891 | 0.8581 | |
| Family Enterobacteriaceae | 7 | 0.8210 (0.6935–0.9720) | 0.022035879 | 0.0040 | 0.0401 | 0.9242 | 2.6442 | 0.8520 | |
| Genus Oscillibacte | 14 | 0.8765(0.7706–0.9969) | 0.044668971 | 0.0252 | 0.0238 | 0.3103 | 21.7925 | 0.0587 | |
| Family Enterobacteriaceae | 7 | 0.8210(0.6935–0.9720) | 0.022035879 | 0.0040 | 0.0401 | 0.9242 | 2.6442 | 0.8520 | |
| GU | Acidaminococcaceae | 7 | 1.0026(1.0005–1.0046) | 0.0156 | 0.0002 | 0.0003 | 0.5816 | 5.5748 | 0.4725 |
| Ruminococcus1 | 10 | 1.0023(1.0004–1.0043) | 0.0203 | 0.0002 | 0.0002 | 0.4685 | 2.0049 | 0.9914 | |
| BacteroidalesS24.7group | 8 | 0.9982(0.9966–0.9997) | 0.0213 | 0.0003 | 0.0003 | 0.4541 | 4.6891 | 0.6978 | |
| FamilyXI | 8 | 0.9989(0.9979–1.0000) | 0.0407 | 0.0003 | 0.0004 | 0.4648 | 5.7265 | 0.5720 | |
| Eubacteriumxylanophilumgroup | 9 | 0.9980(0.9961–1.0000) | 0.0478 | 0.0002 | 0.0002 | 0.4676 | 4.2568 | 0.8332 | |
| Prevotella7 | 11 | 0.9988(0.9979–0.9998) | 0.0142 | 0.0001 | 0.0004 | 0.8963 | 4.5913 | 0.9168 | |
| Victivallis | 10 | 0.9990(0.9981–1.0000) | 0.0496 | 0.0001 | 0.0005 | 0.9088 | 7.3794 | 0.5977 | |
| DU | Eubacteriumeligensgroup | 2 | 0.9966(0.9935–0.9997) | 0.0299 | NA | NA | NA | 0.6616 | 0.4160 |
| Butyricimonas | 6 | 1.0021(1.0001–1.0041) | 0.0432 | 0.0002 | 0.0008 | 0.7886 | 7.2442 | 0.2031 | |
| Enterorhabdus | 2 | 0.9965(0.9938–0.9992) | 0.0104 | NA | NA | NA | 1.0910 | 0.2963 |
GERD, gastroesophageal reflux disease; GU, gastric ulcer; DU, duodenal ulcer; IBS, irritable bowel syndrome; CD, Crohn’s disease; UC, ulcerative colitis; CRC, colorectal cancer; GC, gastric cancer; SNP, single nucleotide polymorphism; MR-PRESSO, Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test; IVW, inverse variance weighting; SE, Standard Deviation.