TABLE 2.

The advantages and limitations of responsive scaffold categories.

Scaffold categories	Advantages	Limitations
Temperature-responsive	Controllable and easy to operate	Temperature ranges are limited
Light-responsive	Little harm to the human body; No direct contact with the lesion area	Penetration depths are either too shallow or too deep; The biological safety of light-sensitive materials need to evaluate
Electric-responsive	Responds quickly and with strong sensitivity	Further investigation is required to examine the alterations in electric field intensity and frequency within organisms
Mechanical-responsive	Sensitive and quick to react	Potential toxicity resulting from the use of crosslinking agents
Magnetic-responsive	Controllable from an external source	The diffusion rate of magnetic particles is high; There exists a potential for toxicity
Ultrasound-responsive	The system can be controlled externally	The controllability of penetration depth is limited; It generates a thermal effect
pH-responsive	Utilizing the distinctions between diseased and normal tissue	Limited range of variation; Low sensitivity
Redox-responsive	Utilizing the distinctions between diseased and normal tissue	The sensitivity is relatively low
Enzyme-responsive	Distinctive biological targeting and catalytic attributes	Different types of enzymes may exhibit cross-reactivity