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. 2023 Nov 17;13:1253418. doi: 10.3389/fonc.2023.1253418

Table 2.

Adjusted hazard ratios comparing all-cause mortality between patients according to clinical and biological markers (n=105).

Univariable models Multivariable model 1 Multivariable model 2 Multivariable model 3
HR (95% CI) P HR (95% CI) P HR (95% CI) P HR (95% CI) P
TNM7 2.403 (1.422-4.060) 0.001 2.403 (1.422-4.060) 0.001 2.408 (1.436-4.039) 8.6 x 10-4 2.283 (1.328-3.924) 0.002
HPV status 0.373 (0.141-0.986) 0.046 0.373 (0.141-0.986) 0.046 0.314 (0.121-0.817) 0.017 0.375 (0.145-0.965) 0.042
Age 1.09 (1.033-1.161) 0.002 1.09 (1.033-1.161) 0.002 1.104 (1.041-1.171) 9.5 x 10-4 1.099 (1.038-1.162) 0.001
Sex 1.462 (0.592- 3.607) 0.410
Smoking status 1.295 (0.907- 1.847) 0.154
Total CD8 (cells/mm2) 0.997 (0.995-0.999) 0.005 0.997 (0.995-0.999) 0.038
Stroma CD8 (cells/mm2) 0.998 (0.995- 1.001) 0.141 0.998 (0.996- 1.001 0.307
Infiltrate CD8 (cells/mm2) 0.994 (0.989- 0.998) 0.008 0.995 (0.990-0.999) 0.032

-: not included in the model.