Table 3.
Adjusted hazard ratios comparing time to progression/relapse between patients according to clinical and biological markers (n=105).
| Univariable models | Multivariable model 1 | Multivariable model 2 | Multivariable model 3 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
| TNM7 | 4.164 (2.176-7.971) | 1.66 x 10-5 | 3.642 (1.974- 6.720) | 3.51 x 10-5 | 3.766 (2.033-6.975) | 2.48 x 10-5 | 3.416 (1.841-6.338) | 9.74 x 10-5 |
| HPV status | 0.543 (0.206-1.432) | 0.217 | – | – | – | – | – | – |
| Age | 1.06 (1.005-1.117) | 0.031 | 1.043 (0.990-1.099) | 0.106 | 1.048 (0.993-1.105) | 0.088 | 1.051 (0.999-1.105) | 0.0508 |
| Sex | 1.031 (0.452- 2.348) | 0.942 | – | – | – | – | – | – |
| Smoking status | 0.666 (0.416 – 1.066) | 0.090 | – | – | – | – | – | – |
| Total CD8 (cells/mm2) | 0.997 (0.996-0.999) | 0.016 | 0.997 (0.995-0.999) | 0.038 | – | – | – | – |
| Stroma CD8 (cells/mm2) | 0.998 (0.995- 1.001) | 0.156 | – | – | 0.998 (0.995- 1.001 | 0.156 | – | – |
| Infiltrate CD8 (cells/mm2) | 0.996 (0.992- 0.999) | 0.031 | – | – | – | – | 0.996 (0.993-1.000) | 0.076 |
-: not included in the model.