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. 2023 Nov 30;82(6):445–457. doi: 10.1097/FJC.0000000000001473

FIGURE 3.

FIGURE 3.

MMP2 KO attenuates the development of hypertension and protein, nephrin, and podocalyxin excretion in SS rats fed a HS diet. A, Temporal changes in MAP in SS rats fed either a LS or a HS diet and MMP2 KO rats fed a HS diet for 3 weeks. B, The time course of changes in protein excretion in SS rats fed either a LS or a HS diet and MMP2 KO rats fed a HS diet for 3 weeks. C, D, The time course of changes in nephrin and podocalyxin excretion, as markers of podocyte injury, in SS rats fed either a LS or a HS diet and MMP2 KO rats fed a HS diet for 3 weeks. Mean values ± SEM are presented. Numbers in parentheses indicate the number of rats studied per group. † indicates P < 0.05 versus the corresponding value in the same strain at week 0. # indicates P < 0.05 versus the corresponding value measured in SS-HS rats.