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. 2023 Nov 30;82(6):445–457. doi: 10.1097/FJC.0000000000001473

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 9. — Effect of MMP2 KO on renal hypertrophy, RBF, GFR, and plasma creatinine levels in STZ-treated diabetic SS rats. A, Kidney weight in age-matched SS rats (SS), STZ-treated SS (SS-STZ), and MMP2 KO (MMP2 KO-STZ) rats, 12 weeks after induction of diabetes. B, RBF was measured by an ultrasound flow probe in age-matched SS rats (SS), STZ-treated SS (SS-STZ) and MMP2 KO (MMP2 KO-STZ) rats 12 weeks after induction of diabetes. C, GFR, measured by the clearance of FITC-inulin in SS, SS-STZ, and MMP2 KO-STZ rats 12 weeks after induction of diabetes. D, Plasma creatinine concentrations in SS, SS-STZ, and MMP2 KO-STZ rats, 12 weeks after induction of diabetes. Mean values ± SEM are presented. * indicates P < 0.05 versus the corresponding value measured in SS rats. # indicates P < 0.05 versus the corresponding value measured in SS-STZ rats.