. Author manuscript; available in PMC: 2024 Dec 1.

Published in final edited form as: Am J Reprod Immunol. 2023 Dec;90(6):e13797. doi: 10.1111/aji.13797

Table 2:

Upstream and downstream regulators of signaling networks

	Name	Network Associated Functions
1	Upstream: Palmitic acid	Cellular function and maintenance, Molecular Transport, Carbohydrate metabolism
	Signalers: AKT & ERK1/2
	Downstream: Creatine
2	Upstream: SIRT1	Small Molecule biochemistry, free radical scavenging, cell signaling
	Signalers: Creb & PPARGC1A
	Downstream: Nitric oxide
3	Upstream: CYP3A4	Carbohydrate metabolism, drug metabolism, endocrine system development and function
3	Downstream: 2-hydroxynevirapine