Table 2. Enriched pathways in up-regulated gene set (Shiny GO Biological Processes 0.76.1) of CNO + MitoQ Cre+ placentas compared to CNO Cre+ determined by bulk RNA sequencing (n = 6 per group, hM3DqF/F dam x Gcm1-Cre+/− sire, GD 14.5).
GTP, guanosine 5′-triphosphate.
| Up-regulated GO biological process | Fold enrichment (CNO + MitoQ Cre+ versus CNO Cre+) | FDR |
|---|---|---|
| GPCR related | ||
| Negative regulation of GTP binding | 29.0 | 0.2 |
| Oxidative stress | ||
| Response to reactive oxygen species | 5.0 | 0.0003 |
| Regulation of response to stress | 2.7 | 3.7 × 10−5 |
| Vascular | ||
| Positive regulation of vasculature development | 3.7 | 0.04 |
| Other | ||
| Negative regulation of apoptotic process | 2.7 | 0.0001 |
| Positive regulation of epithelial cell differentiation | 7.0 | 0.03 |