Appendix 2—table 13. Statin Use Sensitivity Analysis, Unadjusted/Adjusted Odds Ratio for COVID-19-Related Outcomes, Stratified by Region and New York State.
| SARS-CoV-2 Test | COVID-19 Diagnosis | COVID-19 Hospitalization | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Statin Uses versus Non-users | |||||||||||||
| OR | LL | UL | p value | OR | LL | UL | p value | OR | LL | UL | p value | ||
| All | Unadjusted | 0.90 | 0.89 | 0.91 | <0.001 | 0.91 | 0.90 | 0.92 | <0.001 | 1.12 | 1.09 | 1.15 | <0.001 |
| Adjusted | 0.87 | 0.86 | 0.87 | <0.001 | 0.79 | 0.78 | 0.81 | <0.001 | 0.99 | 0.96 | 1.02 | 0.48 | |
| Northeast | Unadjusted | 0.87 | 0.85 | 0.88 | <0.001 | 0.88 | 0.86 | 0.90 | <0.001 | 1.16 | 1.11 | 1.21 | <0.001 |
| Adjusted | 0.85 | 0.84 | 0.87 | <0.001 | 0.77 | 0.75 | 0.78 | <0.001 | 1.03 | 0.98 | 1.07 | 0.22 | |
| Midwest | Unadjusted | 0.97 | 0.95 | 0.99 | 0.02 | 1.10 | 1.07 | 1.14 | <0.001 | 1.27 | 1.19 | 1.36 | <0.001 |
| Adjusted | 0.92 | 0.90 | 0.94 | <0.001 | 0.99 | 0.96 | 1.03 | 0.75 | 1.15 | 1.08 | 1.23 | <0.001 | |
| South | Unadjusted | 0.90 | 0.88 | 0.91 | <0.001 | 0.90 | 0.88 | 0.93 | <0.001 | 1.00 | 0.95 | 1.06 | 0.90 |
| Adjusted | 0.85 | 0.84 | 0.87 | <0.001 | 0.80 | 0.78 | 0.83 | <0.001 | 0.88 | 0.83 | 0.94 | <0.001 | |
| West | Unadjusted | 0.88 | 0.86 | 0.90 | <0.001 | 0.83 | 0.80 | 0.86 | <0.001 | 1.02 | 0.95 | 1.10 | 0.58 |
| Adjusted | 0.86 | 0.83 | 0.88 | <0.001 | 0.71 | 0.68 | 0.74 | <0.001 | 0.87 | 0.80 | 0.94 | <0.001 | |
| New York | Unadjusted | 0.91 | 0.89 | 0.93 | <0.001 | 0.93 | 0.91 | 0.96 | <0.001 | 1.21 | 1.14 | 1.29 | <0.001 |
| Adjusted | 0.92 | 0.90 | 0.95 | <0.001 | 0.79 | 0.77 | 0.82 | <0.001 | 1.05 | 0.98 | 1.13 | 0.15 | |
| BP Users versus BP Non-users among Statin Users | |||||||||||||
| OR | LL | UL | p value | OR | LL | UL | p value | OR | LL | UL | p value | ||
| All | Unadjusted | 0.23 | 0.22 | 0.24 | <0.001 | 0.26 | 0.25 | 0.28 | <0.001 | 0.26 | 0.23 | 0.29 | <0.001 |
| Adjusted | 0.23 | 0.22 | 0.24 | <0.001 | 0.27 | 0.25 | 0.29 | <0.001 | 0.28 | 0.25 | 0.32 | <0.001 | |
| Northeast | Unadjusted | 0.25 | 0.23 | 0.27 | <0.001 | 0.29 | 0.27 | 0.31 | <0.001 | 0.28 | 0.24 | 0.34 | <0.001 |
| Adjusted | 0.25 | 0.23 | 0.27 | <0.001 | 0.29 | 0.27 | 0.32 | <0.001 | 0.32 | 0.26 | 0.38 | <0.001 | |
| Midwest | Unadjusted | 0.24 | 0.22 | 0.27 | <0.001 | 0.22 | 0.19 | 0.25 | <0.001 | 0.21 | 0.16 | 0.27 | <0.001 |
| Adjusted | 0.25 | 0.23 | 0.29 | <0.001 | 0.23 | 0.22 | 0.25 | <0.001 | 0.22 | 0.17 | 0.30 | <0.001 | |
| South | Unadjusted | 0.22 | 0.21 | 0.24 | <0.001 | 0.26 | 0.23 | 0.29 | <0.001 | 0.26 | 0.21 | 0.33 | <0.001 |
| Adjusted | 0.22 | 0.20 | 0.24 | <0.001 | 0.27 | 0.24 | 0.31 | <0.001 | 0.28 | 0.22 | 0.36 | <0.001 | |
| West | Unadjusted | 0.20 | 0.18 | 0.22 | <0.001 | 0.22 | 0.19 | 0.25 | <0.001 | 0.25 | 0.20 | 0.33 | <0.001 |
| Adjusted | 0.20 | 0.18 | 0.22 | <0.001 | 0.23 | 0.20 | 0.27 | <0.001 | 0.28 | 0.21 | 0.36 | <0.001 | |
| New York | Unadjusted | 0.27 | 0.24 | 0.30 | <0.001 | 0.31 | 0.28 | 0.35 | <0.001 | 0.30 | 0.23 | 0.39 | <0.001 |
| Adjusted | 0.28 | 0.25 | 0.32 | <0.001 | 0.31 | 0.28 | 0.35 | <0.001 | 0.33 | 0.25 | 0.44 | <0.001 | |
| BP Users versus BP Non-users among Statin Non-users | |||||||||||||
| OR | LL | UL | p value | OR | LL | UL | p value | OR | LL | UL | p value | ||
| All | Unadjusted | 0.23 | 0.21 | 0.24 | <0.001 | 0.21 | 0.19 | 0.23 | <0.001 | 0.21 | 0.17 | 0.25 | <0.001 |
| Adjusted | 0.24 | 0.22 | 0.25 | <0.001 | 0.23 | 0.21 | 0.25 | <0.001 | 0.25 | 0.21 | 0.30 | <0.001 | |
| Northeast | Unadjusted | 0.25 | 0.22 | 0.27 | <0.001 | 0.22 | 0.20 | 0.25 | <0.001 | 0.24 | 0.19 | 0.31 | <0.001 |
| Adjusted | 0.26 | 0.23 | 0.29 | <0.001 | 0.25 | 0.22 | 0.28 | <0.001 | 0.29 | 0.22 | 0.37 | <0.001 | |
| Midwest | Unadjusted | 0.24 | 0.21 | 0.28 | <0.001 | 0.22 | 0.18 | 0.27 | <0.001 | 0.21 | 0.14 | 0.31 | <0.001 |
| Adjusted | 0.24 | 0.20 | 0.28 | <0.001 | 0.25 | 0.20 | 0.32 | <0.001 | 0.26 | 0.17 | 0.39 | <0.001 | |
| South | Unadjusted | 0.23 | 0.21 | 0.25 | <0.001 | 0.19 | 0.15 | 0.22 | <0.001 | 0.18 | 0.12 | 0.27 | <0.001 |
| Adjusted | 0.24 | 0.21 | 0.27 | <0.001 | 0.21 | 0.17 | 0.25 | <0.001 | 0.22 | 0.15 | 0.33 | <0.001 | |
| West | Unadjusted | 0.19 | 0.17 | 0.22 | <0.001 | 0.18 | 0.15 | 0.22 | <0.001 | 0.16 | 0.11 | 0.25 | <0.001 |
| Adjusted | 0.20 | 0.17 | 0.23 | <0.001 | 0.19 | 0.18 | 0.21 | <0.001 | 0.18 | 0.11 | 0.29 | <0.001 | |
| New York | Unadjusted | 0.26 | 0.23 | 0.30 | <0.001 | 0.26 | 0.22 | 0.30 | <0.001 | 0.27 | 0.19 | 0.39 | <0.001 |
| Adjusted | 0.26 | 0.22 | 0.31 | <0.001 | 0.25 | 0.21 | 0.30 | <0.001 | 0.35 | 0.23 | 0.52 | <0.001 | |
LL: lower 95% confidence interval level; OR: odds ratio; UL: upper 95% confidence interval level.