. 2023 Aug 3;12:e79548. doi: 10.7554/eLife.79548

Appendix 2—table 15. Antidiabetic Use Sensitivity Analysis, Unadjusted/Adjusted Odds Ratio for COVID-19-Related Outcomes, Stratified by Region and New York State.

		Odds of SARS-CoV-2 Test				Odds of COVID-19 Diagnosis				Odds of COVID-19 Hospitalization
		Antidiabetic Users versus Non-users
		OR	LL	UL	p value	OR	LL	UL	p value	OR	LL	UL	p value
All	Unadjusted	0.98	0.97	0.99	0.01	1.15	1.13	1.18	<0.001	1.50	1.45	1.56	<0.001
All	Adjusted	0.92	0.90	0.93	<0.001	0.88	0.86	0.90	<0.001	1.13	1.08	1.18	<0.001
Northeast	Unadjusted	1.00	0.98	1.02	0.92	1.11	1.09	1.14	<0.001	1.55	1.47	1.64	<0.001
Northeast	Adjusted	0.94	0.92	0.97	<0.001	0.84	0.81	0.86	<0.001	1.18	1.11	1.27	<0.001
Midwest	Unadjusted	1.04	1.01	1.08	0.01	1.39	1.33	1.46	<0.001	1.61	1.47	1.76	<0.001
Midwest	Adjusted	0.95	0.91	0.99	0.01	1.11	1.04	1.17	<0.001	1.30	1.17	1.44	<0.001
South	Unadjusted	0.97	0.95	0.99	0.01	1.16	1.12	1.21	<0.001	1.39	1.29	1.50	<0.001
South	Adjusted	0.90	0.88	0.93	<0.001	0.91	0.87	0.95	<0.001	1.04	0.95	1.14	0.40
West	Unadjusted	0.91	0.88	0.94	<0.001	1.07	1.01	1.12	0.01	1.43	1.30	1.58	<0.001
West	Adjusted	0.86	0.82	0.89	<0.001	0.80	0.75	0.85	<0.001	0.97	0.86	1.09	0.60
New York	Unadjusted	1.06	1.03	1.10	<0.001	1.15	1.11	1.19	<0.001	1.59	1.46	1.72	<0.001
New York	Adjusted	1.06	1.02	1.10	0.007	0.87	0.83	0.90	<0.001	1.18	1.07	1.30	0.001
		BP Users versus BP Non-users among Antidiabetic Users
		OR	LL	UL	p value	OR	LL	UL	p value	OR	LL	UL	p value
All	Unadjusted	0.26	0.24	0.28	<0.001	0.29	0.27	0.32	<0.001	0.28	0.24	0.33	<0.001
All	Adjusted	0.26	0.24	0.28	<0.001	0.29	0.27	0.32	<0.001	0.29	0.25	0.34	<0.001
Northeast	Unadjusted	0.28	0.24	0.32	<0.001	0.32	0.28	0.35	<0.001	0.29	0.23	0.36	<0.001
Northeast	Adjusted	0.28	0.24	0.32	<0.001	0.31	0.27	0.35	<0.001	0.30	0.24	0.39	<0.001
Midwest	Unadjusted	0.27	0.22	0.33	<0.001	0.30	0.24	0.38	<0.001	0.28	0.19	0.41	<0.001
Midwest	Adjusted	0.27	0.22	0.34	<0.001	0.32	0.26	0.41	<0.001	0.29	0.19	0.42	<0.001
South	Unadjusted	0.29	0.26	0.33	<0.001	0.31	0.26	0.36	<0.001	0.35	0.26	0.47	<0.001
South	Adjusted	0.30	0.26	0.34	<0.001	0.30	0.25	0.36	<0.001	0.36	0.26	0.48	<0.001
West	Unadjusted	0.19	0.16	0.22	<0.001	0.20	0.17	0.25	<0.001	0.21	0.15	0.30	<0.001
West	Adjusted	0.19	0.16	0.23	<0.001	0.21	0.17	0.26	<0.001	0.22	0.15	0.31	<0.001
New York	Unadjusted	0.33	0.27	0.40	<0.001	0.34	0.29	0.39	<0.001	0.35	0.26	0.49	<0.001
New York	Adjusted	0.32	0.26	0.40	<0.001	0.32	0.28	0.36	<0.001	0.40	0.28	0.56	<0.001
		BP Users versus BP Non-users among Antidiabetic Non-users
		OR	LL	UL	p value	OR	LL	UL	p value	OR	LL	UL	p value
All	Unadjusted	0.24	0.23	0.26	<0.001	0.24	0.22	0.26	<0.001	0.24	0.20	0.29	<0.001
All	Adjusted	0.25	0.23	0.27	<0.001	0.25	0.23	0.28	<0.001	0.27	0.22	0.33	<0.001
Northeast	Unadjusted	0.24	0.22	0.28	<0.001	0.26	0.22	0.29	<0.001	0.25	0.19	0.34	<0.001
Northeast	Adjusted	0.25	0.22	0.29	<0.001	0.27	0.24	0.32	<0.001	0.28	0.20	0.39	<0.001
Midwest	Unadjusted	0.27	0.22	0.32	<0.001	0.22	0.17	0.30	<0.001	0.26	0.16	0.42	<0.001
Midwest	Adjusted	0.28	0.24	0.31	<0.001	0.23	0.17	0.31	<0.001	0.26	0.16	0.45	<0.001
South	Unadjusted	0.24	0.21	0.27	<0.001	0.25	0.20	0.30	<0.001	0.29	0.20	0.43	<0.001
South	Adjusted	0.24	0.21	0.27	<0.001	0.24	0.21	0.28	<0.001	0.33	0.22	0.49	<0.001
West	Unadjusted	0.23	0.20	0.27	<0.001	0.18	0.14	0.24	<0.001	0.13	0.07	0.23	<0.001
West	Adjusted	0.23	0.20	0.28	<0.001	0.20	0.15	0.26	<0.001	0.15	0.08	0.28	<0.001
New York	Unadjusted	0.30	0.25	0.37	<0.001	0.30	0.25	0.36	<0.001	0.22	0.14	0.36	<0.001
New York	Adjusted	0.30	0.25	0.37	<0.001	0.31	0.25	0.37	<0.001	0.24	0.14	0.41	<0.001

LL: lower 95% confidence interval level; OR: odds ratio; UL: upper 95% confidence interval level.