. 2023 Aug 3;12:e79548. doi: 10.7554/eLife.79548

Appendix 2—table 16. Antidepressant Use Sensitivity Analysis, Unadjusted/Adjusted Odds Ratio for COVID-19-Related Outcomes, Stratified by Region and New York State.

		Odds of SARS-CoV-2 Test				Odds of COVID-19 Diagnosis				Odds of COVID-19 Hospitalization
		Antidepressant Users versus Non-users
		OR	LL	UL	p value	OR	LL	UL	p value	OR	LL	UL	p value
All	Unadjusted	1.04	1.03	1.05	<0.001	0.71	0.70	0.72	<0.001	0.81	0.78	0.83	<0.001
All	Adjusted	1.00	0.99	1.01	0.61	0.65	0.64	0.66	<0.001	0.75	0.73	0.78	<0.001
Northeast	Unadjusted	1.01	0.99	1.02	0.54	0.71	0.69	0.72	<0.001	0.84	0.80	0.88	<0.001
Northeast	Adjusted	0.97	0.95	0.99	0.001	0.65	0.63	0.66	<0.001	0.77	0.73	0.82	<0.001
Midwest	Unadjusted	1.10	1.08	1.12	<0.001	0.75	0.72	0.78	<0.001	0.84	0.78	0.90	<0.001
Midwest	Adjusted	1.05	1.03	1.07	<0.001	0.69	0.66	0.71	<0.001	0.78	0.73	0.84	<0.001
South	Unadjusted	1.04	1.02	1.05	<0.001	0.68	0.66	0.70	<0.001	0.74	0.70	0.79	<0.001
South	Adjusted	0.99	0.98	1.01	0.49	0.64	0.62	0.66	<0.001	0.72	0.68	0.77	<0.001
West	Unadjusted	1.04	1.02	1.06	0.00	0.70	0.67	0.73	<0.001	0.77	0.70	0.84	<0.001
West	Adjusted	0.99	0.97	1.02	0.46	0.64	0.61	0.66	<0.001	0.70	0.64	0.77	<0.001
New York	Unadjusted	1.00	0.97	1.03	0.86	0.77	0.74	0.80	<0.001	0.83	0.76	0.91	<0.001
New York	Adjusted	0.98	0.95	1.01	0.27	0.72	0.70	0.75	<0.001	0.77	0.70	0.85	<0.001
		BP Users versus BP Non-users among Antidepressant Users
		OR	LL	UL	p value	OR	LL	UL	p value	OR	LL	UL	p value
All	Unadjusted	0.27	0.26	0.28	<0.001	0.30	0.28	0.32	<0.001	0.31	0.27	0.36	<0.001
All	Adjusted	0.27	0.25	0.28	<0.001	0.30	0.28	0.32	<0.001	0.33	0.28	0.38	<0.001
Northeast	Unadjusted	0.28	0.26	0.31	<0.001	0.33	0.30	0.37	<0.001	0.36	0.29	0.45	<0.001
Northeast	Adjusted	0.28	0.25	0.30	<0.001	0.32	0.29	0.36	<0.001	0.37	0.29	0.47	<0.001
Midwest	Unadjusted	0.30	0.27	0.34	<0.001	0.26	0.22	0.31	<0.001	0.25	0.18	0.34	<0.001
Midwest	Adjusted	0.30	0.26	0.34	<0.001	0.27	0.22	0.33	<0.001	0.26	0.18	0.36	<0.001
South	Unadjusted	0.26	0.24	0.29	<0.001	0.27	0.23	0.31	<0.001	0.32	0.24	0.41	<0.001
South	Adjusted	0.26	0.24	0.28	<0.001	0.27	0.23	0.32	<0.001	0.32	0.24	0.43	<0.001
West	Unadjusted	0.25	0.22	0.28	<0.001	0.27	0.22	0.32	<0.001	0.29	0.20	0.41	<0.001
West	Adjusted	0.24	0.21	0.27	<0.001	0.29	0.28	0.30	<0.001	0.33	0.23	0.48	<0.001
New York	Unadjusted	0.30	0.26	0.34	<0.001	0.33	0.28	0.38	<0.001	0.24	0.16	0.36	<0.001
New York	Adjusted	0.30	0.25	0.34	<0.001	0.31	0.27	0.37	<0.001	0.25	0.16	0.39	<0.001
		BP Users versus BP Non-users among Antidepressant Non-users
		OR	LL	UL	p value	OR	LL	UL	p value	OR	LL	UL	p value
All	Unadjusted	0.20	0.19	0.22	<0.001	0.22	0.20	0.24	<0.001	0.24	0.20	0.28	<0.001
All	Adjusted	0.21	0.19	0.22	<0.001	0.23	0.21	0.25	<0.001	0.27	0.22	0.32	<0.001
Northeast	Unadjusted	0.21	0.19	0.24	<0.001	0.23	0.20	0.26	<0.001	0.25	0.19	0.32	<0.001
Northeast	Adjusted	0.22	0.19	0.25	<0.001	0.24	0.22	0.25	<0.001	0.29	0.22	0.39	<0.001
Midwest	Unadjusted	0.22	0.19	0.26	<0.001	0.23	0.18	0.28	<0.001	0.28	0.19	0.39	<0.001
Midwest	Adjusted	0.21	0.18	0.25	<0.001	0.26	0.24	0.27	<0.001	0.32	0.22	0.47	<0.001
South	Unadjusted	0.20	0.18	0.22	<0.001	0.21	0.18	0.25	<0.001	0.21	0.15	0.30	<0.001
South	Adjusted	0.20	0.18	0.23	<0.001	0.23	0.19	0.27	<0.001	0.22	0.16	0.32	<0.001
West	Unadjusted	0.18	0.16	0.21	<0.001	0.20	0.16	0.25	<0.001	0.20	0.13	0.30	<0.001
West	Adjusted	0.19	0.16	0.22	<0.001	0.20	0.20	0.21	<0.001	0.22	0.14	0.35	<0.001
New York	Unadjusted	0.26	0.22	0.32	<0.001	0.27	0.23	0.32	<0.001	0.29	0.19	0.43	<0.001
New York	Adjusted	0.26	0.23	0.30	<0.001	0.26	0.22	0.32	<0.001	0.35	0.22	0.54	<0.001

LL: lower 95% confidence interval level; OR: odds ratio; UL: upper 95% confidence interval level.