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. 2023 Aug 3;12:e79548. doi: 10.7554/eLife.79548

Appendix 2—table 17. “Bone-Rx” Cohort (All Regions), Patient Characteristics Pre/Post Match.

"Bone-Rx" Cohort / All Observations Unmatched "Bone-Rx" Cohort / All Observations Matched
All BP Non-user BP User p-value All BP Non-user BP User p-value
N % N % N % N % N % N %
All Patients 502,895 100.0% 50,844 10.1% 452,051 89.9% 100,996 100.0% 50,498 50.0% 50,498 50.0%
Age
≤20 1,164 0.2% 36 0.1% 1,128 0.2% <0.001 67 0.1% 36 0.1% 31 0.1% 0.97
21-40 3,501 0.7% 410 0.8% 3,091 0.7% 790 0.8% 403 0.8% 387 0.8%
41-50 9,631 1.9% 1,080 2.1% 8,551 1.9% 2,107 2.1% 1,069 2.1% 1,038 2.1%
51-60 72,139 14.3% 6,418 12.6% 65,721 14.5% 12,777 12.7% 6,395 12.7% 6,382 12.6%
61-70 171,687 34.1% 14,809 29.1% 156,878 34.7% 29,509 29.2% 14,751 29.2% 14,758 29.2%
71-80 157,877 31.4% 16,152 31.8% 141,725 31.4% 32,129 31.8% 16,055 31.8% 16,074 31.8%
≥81 86,896 17.3% 11,939 23.5% 74,957 16.6% 23,617 23.4% 11,789 23.3% 11,828 23.4%
Gender
Female 451,790 89.8% 44,354 87.2% 407,436 90.1% <0.001 88,552 87.7% 44,235 87.6% 44,317 87.8% 0.43
Male 51,105 10.2% 6,490 12.8% 44,615 9.9% 12,444 12.3% 6,263 12.4% 6,181 12.2%
Region
Midwest 85,391 17.0% 9,424 18.5% 75,967 16.8% <0.001 18,720 18.5% 9,360 18.5% 9,360 18.5% 1.00
Northeast 135,867 27.0% 16,139 31.7% 119,728 26.5% 31,986 31.7% 15,993 31.7% 15,993 31.7%
South 178,118 35.4% 17,232 33.9% 160,886 35.6% 34,280 33.9% 17,140 33.9% 17,140 33.9%
West 103,519 20.6% 8,049 15.8% 95,470 21.1% 16,010 15.9% 8,005 15.9% 8,005 15.9%
Insurance
Commercial 164,150 32.6% 17,092 33.6% 147,058 32.5% <0.001 33,977 33.6% 16,963 33.6% 17,014 33.7% 0.91
Dual 33,969 6.8% 2,562 5.0% 31,407 6.9% 5,056 5.0% 2,547 5.0% 2,509 5.0%
Medicaid 84,514 16.8% 7,034 13.8% 77,480 17.1% 13,925 13.8% 6,986 13.8% 6,939 13.7%
Medicare 220,262 43.8% 24,156 47.5% 196,106 43.4% 48,038 47.6% 24,002 47.5% 24,036 47.6%
PCP Visit 2019
No 181,996 36.2% 18,130 35.7% 163,866 36.2% 0.009 35,943 35.6% 17,979 35.6% 17,964 35.6% 0.92
Yes 320,899 63.8% 32,714 64.3% 288,185 63.8% 65,053 64.4% 32,519 64.4% 32,534 64.4%
Continuous Outcomes
mean SD mean SD mean SD p-value mean SD mean SD mean SD p-value
CCI 1.05 1.91 1.99 2.71 0.95 1.76 <0.001 1.93 2.59 1.93 2.60 1.92 2.59 0.76

BP: bisphosphonate; CCI: Charlson Comorbidity Index; PCP: primary care physician; SD: standard deviation.