Appendix 2—table 42. Antidepressant Cohort (All Regions), Patient Characteristics Pre/Post Match.
| All Observations by Antidepressant Use: Unmatched | All Observations by Antidepressant Use: Matched | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | DEPR Non-users | DEPR Users | p-value | All | DEPR Non-users | DEPR Users | p-value | |||||||
| N | % | N | % | N | % | N | % | N | % | N | % | |||
| All Patients | 7,906,603 | 100.0% | 6,335,598 | 80.1% | 1,571,005 | 19.9% | 3,072,096 | 100.0% | 1,536,048 | 50.0% | 1,536,048 | 50.0% | ||
| Age | ||||||||||||||
| ≤20 | 1,840,050 | 23.3% | 1,750,435 | 27.6% | 89,615 | 5.7% | <0.001 | 179,136 | 5.8% | 89,565 | 5.8% | 89,571 | 5.8% | 1.00 |
| 21-40 | 1,446,999 | 18.3% | 1,128,316 | 17.8% | 318,683 | 20.3% | 631,186 | 20.5% | 315,593 | 20.5% | 315,593 | 20.5% | ||
| 41-50 | 925,309 | 11.7% | 683,455 | 10.8% | 241,854 | 15.4% | 466,681 | 15.2% | 233,336 | 15.2% | 233,345 | 15.2% | ||
| 51-60 | 1,250,190 | 15.8% | 899,512 | 14.2% | 350,678 | 22.3% | 667,305 | 21.7% | 333,650 | 21.7% | 333,655 | 21.7% | ||
| 61-70 | 1,181,261 | 14.9% | 879,560 | 13.9% | 301,701 | 19.2% | 592,345 | 19.3% | 296,182 | 19.3% | 296,163 | 19.3% | ||
| 71-80 | 783,775 | 9.9% | 613,922 | 9.7% | 169,853 | 10.8% | 338,594 | 11.0% | 169,295 | 11.0% | 169,299 | 11.0% | ||
| ≥81 | 479,019 | 6.1% | 380,398 | 6.0% | 98,621 | 6.3% | 196,849 | 6.4% | 98,427 | 6.4% | 98,422 | 6.4% | ||
| Gender | ||||||||||||||
| Female | 4,670,960 | 59.1% | 3,527,859 | 55.7% | 1,143,101 | 72.8% | <0.001 | 2,219,179 | 72.2% | 1,109,580 | 72.2% | 1,109,599 | 72.2% | 0.98 |
| Male | 3,235,643 | 40.9% | 2,807,739 | 44.3% | 427,904 | 27.2% | 852,917 | 27.8% | 426,468 | 27.8% | 426,449 | 27.8% | ||
| Region | ||||||||||||||
| Midwest | 1,467,802 | 18.6% | 1,120,969 | 17.7% | 346,833 | 22.1% | <0.001 | 671,016 | 21.8% | 335,508 | 21.8% | 335,508 | 21.8% | 1.00 |
| Northeast | 2,152,560 | 27.2% | 1,765,134 | 27.9% | 387,426 | 24.7% | 766,046 | 24.9% | 383,023 | 24.9% | 383,023 | 24.9% | ||
| South | 3,042,604 | 38.5% | 2,428,383 | 38.3% | 614,221 | 39.1% | 1,192,058 | 38.8% | 596,029 | 38.8% | 596,029 | 38.8% | ||
| West | 1,243,637 | 15.7% | 1,021,112 | 16.1% | 222,525 | 14.2% | 442,976 | 14.4% | 221,488 | 14.4% | 221,488 | 14.4% | ||
| Insurance | ||||||||||||||
| Commercial | 3,938,603 | 49.8% | 3,230,475 | 51.0% | 708,128 | 45.1% | <0.001 | 1,415,351 | 46.1% | 707,675 | 46.1% | 707,676 | 46.1% | 1.00 |
| Dual | 156,497 | 2.0% | 94,682 | 1.5% | 61,815 | 3.9% | 109,676 | 3.6% | 54,836 | 3.6% | 54,840 | 3.6% | ||
| Medicaid | 2,594,500 | 32.8% | 2,083,688 | 32.9% | 510,812 | 32.5% | 972,897 | 31.7% | 486,446 | 31.7% | 486,451 | 31.7% | ||
| Medicare | 1,217,003 | 15.4% | 926,753 | 14.6% | 290,250 | 18.5% | 574,172 | 18.7% | 287,091 | 18.7% | 287,081 | 18.7% | ||
| PCP Visit 2019 | ||||||||||||||
| No | 4,283,697 | 54.2% | 3,672,879 | 58.0% | 610,818 | 38.9% | <0.001 | 1,210,520 | 39.4% | 605,256 | 39.4% | 605,264 | 39.4% | 0.99 |
| Yes | 3,622,906 | 45.8% | 2,662,719 | 42.0% | 960,187 | 61.1% | 1,861,576 | 60.6% | 930,792 | 60.6% | 930,784 | 60.6% | ||
| Continuous Outcomes | ||||||||||||||
| mean | SD | mean | SD | mean | SD | p-value | mean | SD | mean | SD | mean | SD | p-value | |
| CCI | 0.62 | 1.38 | 0.55 | 1.29 | 0.90 | 1.65 | <0.001 | 0.87 | 1.60 | 0.87 | 1.60 | 0.87 | 1.60 | 0.98 |
CCI: Charlson Comorbidity Index; DEPR: antidepressant; PCP: primary care physician; SD: standard deviation.